Itiye elimnyama, elivutshelwe ngokuphelele, yitiye elisetshenziswa kakhulu emhlabeni. Ngenkathi icutshungulwa, kufanele ibune, igingqike futhi ivubele, okubangela ukusabela okuyinkimbinkimbi kwamakhemikhali ezinto eziqukethwe emaqabunga etiye futhi ekugcineni kuzala ukunambitheka kwayo okuyingqayizivele nomthelela wezempilo. Muva nje, ithimba labacwaningi eliholwa nguProfesa WANG Yuefei ovela eKolishi Lezolimo Nezobuchwepheshe, i-Zhejiang University, lenze uchungechunge lwenqubekelaphambili mayelana nokwakheka kwekhwalithi kanye nomsebenzi wezempilo wetiye elimnyama.

Ngokusebenzisa ukuhlolwa kwezinzwa kanye ne-metabolomics ukuhlaziya imiphumela yemingcele yokucubungula ehlukene kumakhompiyutha aguquguqukayo nangaguquguquki wetiye elimnyama le-Zijuan, ithimba lithole ukuthi i-phenylacetic acid ne-glutamine ahlotshaniswa kakhulu nephunga nokunambitheka kwetiye elimnyama le-Zijuan, ngokulandelana, ngaleyo ndlela inikeze ireferensi yokwenziwa kahle kwenqubo yokucubungula itiye elimnyama le-Zijuan (Zhao et al., LWT -Isayensi Yokudla Nobuchwepheshe, 2020). Ezifundweni ezalandela, bathola ukuthi ukugxila komoya-mpilo kungakhuthaza ama-catechin, i-flavonoid glycosides nama-phenolic acid, kanye ne-catechins oxidation ingasheshisa ukuwohloka kwama-amino acid ukuze enze ama-aldehyde aguquguqukayo futhi akhuthaze ukugcwala kwama-phenolic acid, ngaleyo ndlela kwehlise ukuqaqamba kwenhliziyo nokubaba kanye nokukhulisa umami. , enikeza ukuqonda kwenoveli ekubunjweni okufanelekile kwetiye elimnyama. Lokhu okutholwe ocwaningweni kwashicilelwa esihlokweni esithi “Ukuvutshelwa okunothiswe nge-oksijeni kuthuthukisa ukunambitheka kwetiye elimnyama ngokunciphisa ama-metabolites ababayo kanye ne-astringent” kujenali.Food Research InternationalngoJulayi, 2021.

Izinguquko kuma-metabolites angaguquki ngesikhathi sokucubungula zithinta kokubili ikhwalithi kanye nomsebenzi wezempilo ongaba khona wetiye elimnyama. NgoNovemba 2021, iqembu lashicilela indatshana yokufinyelela evulekile enesihloko esithi "Ukuguqulwa kwe-nonvolatile metabolite ngesikhathi sokucutshungulwa kwetiye elimnyama laseZijuan kuthinta amandla okuvikela kuma-HOEC achayeke ku-nicotine" kujenali.Ukudla & Umsebenzi. Lolu cwaningo lubonise ukuthi i-leucine, isoleucine, ne-tyrosine kwakuyimikhiqizo eyinhloko ye-hydrolysis ngesikhathi sokubuna, kanye ne-theaflavin-3-gallate (TF-3-G), theaflavin-3'-gallate (TF-3'-G) kanye ne-theaflavin-3 I-3'-gallate (TFDG) yakhiwe kakhulu ngesikhathi sokugingqika. Ngaphezu kwalokho, i-oxidation ye-flavonoid glycosides, i-catechin namacatechin e-dimeric kwenzeka ngesikhathi sokuvutshelwa. Ngesikhathi sokumiswa, ukuguqulwa kwe-amino acid kwaba okubusayo. Izinguquko ze-theaflavins, amanye ama-amino acid kanye nama-flavonoid glycosides kube nemiphumela ephawulekayo ekumelana netiye elimnyama le-Zijuan ekulimaleni kweseli yomlomo ye-epithelial eyenziwa yi-nicotine, okubonisa ukuthi ukunothiswa kwezithako ezithile ezisebenzayo kanye nokuthuthukiswa kwemisebenzi ekhethekile yetiye elimnyama ngokwenza ngcono. inqubo yokukhiqiza itiye elimnyama ingase ibe umqondo ohlakaniphile wokucubungula umkhiqizo wetiye.

NgoZibandlela wezi-2021, ithimba lashicilela enye indatshana enesihloko esithi “Itiye Elimnyama Linciphisa Ukulimala Kwephaphu Okubangelwa Izinhlayiya Nge-Gut-Lung Axis Kumagundane”Ijenali yeI-Agricultural and Food Chemistry. Lolu cwaningo lubonise ukuthi i-PM (i-particle matter) -amagundane adaluliwe abonise ingcindezi ye-oxidative kanye nokuvuvukala emaphashini, okungadanjiswa kakhulu ukumnika kwansuku zonke kwe-Zijuan itiye elimnyama ngendlela encike ekugxilweni. Kuyathakazelisa ukuthi kokubili ingxenye ye-ethanol-soluble (ES) kanye nengxenye ye-ethanol precipitate (EP) ibonise imiphumela engcono kunaleyo ye-TI. Ngaphezu kwalokho, i-fecal microbiota transplantation (FMT) yembula ukuthi i-gut microbiota yahlelwa kabusha ngokuhlukile yi-TI futhi izingxenyana zayo zakwazi ukudambisa ngokuqondile ukulimala okubangelwa ama-PM. Ngaphezu kwalokho, i-I-Lachnospiraceae_NK4A136_groupkungaba i-microbe gut microbe enomthelela ekuvikelweni kwe-EP. "Le miphumela ibonise ukuthi ukuthathwa kwansuku zonke kwetiye elimnyama kanye nezingxenyana zalo, ikakhulukazi i-EP, kungase kunciphise ukulimala kwamaphaphu okubangelwa yi-PM ngokusebenzisa i-axis yamaphaphu kumagundane, ngakho-ke inikeza izinkomba zethiyori zomsebenzi wezempilo wetiye elimnyama," kusho u-Wang.