Itiye Elimnyama, elivuthiswe ngokuphelele, itiye elidla kakhulu emhlabeni. Ngenkathi kucutshungulwa, kufanele kubhebhetheke, ukugoqa nokuvutshelwa, okubangela ukusabela okuyinkimbinkimbi kwe-biochemical kwezinto eziqukethwe amaqabunga etiye futhi ekugcineni kuzala ukunambitheka kwayo okuyingqayizivele kanye nomphumela wezempilo. Muva nje, ithimba lokucwaninga eliholwa nguProf. Wang yuefei elivela ekolishi lezolimo ne-biotechnology, iZhejiang University, lenze uchungechunge lwentuthuko ngokuya ngeseluleko sekhwalithi esimnyama.

Ngokusebenzisa ukuhlolwa kwemizwa kanye metabolomics ukuhlaziya imiphumela yamapharamitha ahlukene wokucubungula ezinhlangeni ezinobuthakathaka kanye ne-glutamine zixhumene kakhulu nephuzi elimnyama, ngokulandelana, ngaleyo ndlela zinikeza inkomba yokwenziwa kwendlela yokusebenza ye-ZUJUAN TEA (ZHAOO ET al., lwt -ISayensi Yokudla nobuchwepheshe, 2020). Ezifundweni ezalandela, bathola ukuthi ukugxila komoya-mpilo kungakhuthaza ama-catechins, ama-glycosides we-flavonoid nama-oxidation we-phenolic, kanye nokunciphisa i-astringency kanye nokunciphisa i-astretchection kanye nokwehlisa ukuthuthukisa ukuqina kwenoveli itiye elimnyama. Lokhu okutholakele kocwaningo kushicilelwe entweni enesihloko esithi "Ukuvunyelwa Okuvinjelwe umoya-mpilo kuthuthukisa ukunambitheka kwetiye elimnyama ngokunciphisa ama-metabolites abuhlungu nakwezinkanyeziUkudla Ukucwaninga InternationalNgoJulayi, 2021.

Izinguquko kuma-metabolites angelonatile ngesikhathi sokucutshungulwa zithinta ikhwalithi kanye nomsebenzi wezempilo ongaba khona wetiye elimnyama. NgoNovemba 2021, iqembu lishicilele i-athikili evulekile enesihloko esithi "Ukuguqulwa kweMetabolile Envolatile ngesikhathi sokulungiswa kwetiye elimnyama le-Zizuan kuthinta amandla okuvikela kuma-holecs avezwe ku-nicotine" kwiphephabhukuUkudla nokusebenza. Lolu cwaningo lukhombisile ukuthi i-leucine, i-isoleosine, kanti i-tytrosine yayiyimikhiqizo esemqoka ye-hydrolysis ngesikhathi sokubuna, kanye ne-terflavin-3-gallote (TF-3'-galtate (TF-3'-galtate (TF-3'-galtate (TF-3'-galtate (TF-3'-galtate (TFGHG (TFDG) yakhiwa ngokuyinhloko ngesikhathi sokugibela. Ngaphezu kwalokho, i-oxidation of flavonoid glycosides, Catechins kanye ne-dimic catechins kwenzeka ngesikhathi sokuvutshelwa. Ngesikhathi somasha, ukuguqulwa kwe-amino acid kwaqala ukuvelela. Izinguquko zeTheaflavins, amanye ama-amino acid kanye ne-glycosides ye-flavonoid abe nemiphumela ebalulekile ekumelaneni netiye elimnyama le-zicotine ku-nicotine deal tea, ekhombisa ukuthi ukucebisa okukhethekile kwe-epithelial tea ngokuthuthuka kwetiye elimnyama kungaba ngumqondo wobuhlakani wokucutshungulwa komkhiqizo wetiye.

Ngo-December 2021, iqembu lalishicilela enye i-athikili elithi "itiye elimnyama lisebenzisa ukulimala kwamaphaphu amaphaphu nge-axis ye-gut-lung egunjini" kuIjenali yeI-Chemistry yezolimo neyokudla. Lolu cwaningo lubonise ukuthi i-PM (udaba lokubopha) -I-Exposed Mice ekhombisa ukucindezelwa okuxinative kanye nokuvuvukala emaphashini, okungahle kuncishiswe kakhulu ngokudla kwansuku zonke kwetiye elimnyama. Kuyathakazelisa ukuthi, zombili izingxenyana ze-ethanol-soluble (es) kanye nengxenyenamba ye-ethanol eqondile (EP) ebonise imiphumela engcono kunaleyo ye-TI. Ngaphezu kwalokho, ukufakelwa kwe-microbiotal ye-ficrobiota (FMT) kuveze ukuthi amasu e-microbiota asetshenziswe kabusha nge-TI kanti izingxenyana zawo zakwazi ukubulawa ngokuqondile ukulimala okuphoqelelwa yi-PMS. Ngaphezu kwalokho, TheI-Lachnospiraceae_nk4a136_Groupkungaba yi-microbe emihle ye-gut ifaka isandla ekuvikelweni kwe-EP. "Le miphumela ikhombisile ukuthi ukudla okwenziwa nsuku zonke kwetiye elimnyama kanye nezingxenyana zalo, ikakhulukazi amaphaphu ukulimala kwamaphaphu nge-axis ye-gut-lung nge-axis ye-gut-lung emugqeni," kusho uWang.