Iti emnyama, evundiswe ngokupheleleyo, yeyona isetyenziswa kakhulu kwihlabathi. Ngelixa icutshungulwa, kufuneka ibune, iqengqeleke kwaye ivundiswe, nto leyo ebangela ukusabela okuntsonkothileyo kwe-biochemical yezinto eziqulethwe kumagqabi eti kwaye ekugqibeleni izale incasa yayo ekhethekileyo kunye nesiphumo sempilo. Kungekudala, iqela lophando elikhokelwa nguProf WANG Yuefei ovela kwiKholeji yezoLimo kunye ne-Biotechnology, iYunivesithi yaseZhejiang, uye wenza uchungechunge lwenkqubela phambili malunga nokubunjwa komgangatho kunye nomsebenzi wezempilo wetiyi emnyama.

Ngokusebenzisa uvandlakanyo lweemvakalelo kunye ne-metabolomics ukuhlalutya iziphumo zeeparamitha ezahlukeneyo zokusetyenzwa kwiikhompawundi eziguquguqukayo nezingaguquguqukiyo zeti emnyama yeZijuan, iqela lafumanisa ukuba i-phenylacetic acid kunye ne-glutamine zihambelana kakhulu nevumba kunye nencasa yeti emnyama yeZijuan, ngokulandelanayo, ngaloo ndlela ibonelela ngereferensi yokwenziwa kobuchule bokusebenza kweti emnyama yeZijuan (Zhao et al., LWT -Inzululwazi yoKutya kunye neTeknoloji, 2020). Kwizifundo ezilandelayo, bafumanisa ukuba ugxininiso lwe-oksijini lunokukhuthaza i-catechins, i-flavonoid glycosides kunye ne-phenolic acids, kunye ne-catechins oxidation inokukhawulezisa ukuthotywa kwe-amino acids ukwenza i-aldehydes eguquguqukayo kunye nokukhuthaza i-oxidation ye-phenolic acids, ngaloo ndlela inciphisa i-astringency kunye ne-butterness kunye nokwandisa umami. , enika ingqiqo entsha ekubunjweni okufanelekileyo kweti emnyama. Ezi ziphumo zophando zipapashwe kwinqaku elinesihloko esithi "Ukuvutshelwa kwe-oxygen-enriched kuphucula incasa yeti emnyama ngokunciphisa i-metabolites ekrakra kunye ne-astringent" kwijenali.Uphando Lokutya lwamazwe ngamazwengoJulayi, 2021.

Utshintsho kwi-metabolites engaguqukiyo ngexesha lokucubungula luchaphazela zombini umgangatho kunye nomsebenzi wezempilo onokuthi ube khona weti emnyama. NgoNovemba ka-2021, iqela lapapasha inqaku elivulelekayo elinesihloko esithi "Utshintsho lwe-metabolite olungaguqukiyo ngexesha lokusetyenzwa kweti emnyama yaseZijuan luchaphazela amandla okukhusela kwi-HOECs evezwe kwi-nicotine" kwijenali.Ukutya & Umsebenzi. Olu phononongo lubonise ukuba i-leucine, isoleucine, kunye ne-tyrosine zezona mveliso ziphambili ze-hydrolysis ngexesha lokubuna, kunye ne-theaflavin-3-gallate (TF-3-G), theaflavin-3'-gallate (TF-3'-G) kunye ne-theaflavin-3 I-3'-gallate (TFDG) yenziwe ikakhulu ngexesha lokuqengqeleka. Ngaphezu koko, i-oxidation ye-flavonoid glycosides, i-catechin kunye ne-dimeric catechins yenzeke ngexesha lokuvutshelwa. Ngexesha lokumisa, ukuguqulwa kwe-amino acid kwaba yinto elawulayo. Utshintsho lwe-theaflavins, ezinye ii-amino acids kunye ne-flavonoid glycosides zineziphumo ezibalulekileyo ekuxhathiseni iti emnyama yeZijuan kwi-nicotine-induced human oral epithelial cell injury, ebonisa ukuba ukutyeba kwezithako ezithile ezisebenzayo kunye nokwandiswa kwemisebenzi ekhethekileyo yeti emnyama ngokuphucula. inkqubo yokwenziwa kweti emnyama inokuba ngumbono okrelekrele wokusetyenzwa kwemveliso yeti.

NgoDisemba ka-2021, iqela lapapasha elinye inqaku elinesihloko esithi "Iti emnyama inciphisa ukwenzakala okubangelwa yiLung nge-Gut-Lung Axis kwiMice"Ijenali yeIKhemistri yezoLimo kunye nokutya. Olu phononongo lubonise ukuba i-PM (into ethile)-eveziweyo iimpuku zibonise uxinzelelo lwe-oxidative kunye nokudumba kwimiphunga, okunokuthi kuncitshiswe kakhulu kukuthathwa kwemihla ngemihla kwe-Zijuan iti emnyama ngendlela exhomekeke kugxininiso. Okubangela umdla kukuba, zombini i-ethanol-soluble fraction (ES) kunye ne-ethanol precipitate fraction (EP) ibonise iziphumo ezingcono kunezo ze-TI. Ngaphezu koko, i-fecal microbiota transplantation (FMT) ibonise ukuba i-gut microbiota yatshintshwa ngokwahlukileyo yi-TI kwaye amaqhezu ayo akwazi ukuphelisa ngokuthe ngqo ukulimala okubangelwa yi-PMs. Ukongeza, iLachnospiraceae_NK4A136_iqelainokuba ngundoqo we-gut microbe enegalelo ekukhuselweni kwe-EP. "Ezi ziphumo zibonise ukuba ukuthathwa kwansuku zonke kweeti ezimnyama kunye namaqhezu ayo, ngakumbi i-EP, kunokunciphisa ukulimala kwe-PM-induced lung ngokusebenzisa i-gut-lung axis kwiigundane, ngoko ke ukubonelela ngeengxelo zethiyori kumsebenzi wezempilo weti emnyama," watsho uWang.