Ingaruka zo kurwanya indumu no kuyangiza icyayi cyanditswe hakiri kare nka Shennong ibyatsi. Hamwe niterambere ryubumenyi n'ikoranabuhanga, abantu bishyura byinshi
Kandi byinshi byita kumikorere yubuzima bwicyayi. Icyayi gikize muri polyphenol y'icyayi, icyayi polsaketi, Theanune, cafeyine n'ibindi bigize imikorere. Ifite ubushobozi bwo gukumira umubyibuho ukabije, diyabete, gutwika indwara zidakira n'izindi ndwara.
Ibara ry'amara rifatwa nk '"urugingo rufite akamaro" na "urugingo rwa Endocrine", rugizwe na mikorobe igera ku 100 mu mara. Flora y'inyama ifitanye isano rya bugufi no kubaho k'umubyibuho ukabije, diyabete, hypertension n'izindi ndwara.
Mu myaka yashize, byinshi kandi byinshi byasanze ingaruka zidasanzwe zubuzima bwicyayi zishobora guterwa n'imikoranire hagati yicyayi, ibice bikora hamwe na flora yinyamanswa. Umubare munini wuburayi wemeje ko polyphenol yicyayi hamwe nibinyabuzima bike bishobora guhindurwa kandi bigakoreshwa na mikorobe mumishinga nini, bikaviramo inyungu zubuzima. Ariko, uburyo bwo gukorana hagati yicyayi na flora yinyama ntisobanutse. Niba arizo ngaruka zitaziguye za metabolite yibice byibihugu bikora byigice cya mikorobe yicyayi, cyangwa ingaruka zitaziguye zitera imikurire yimishinga yingenzi mumikino yo gutanga Metabolite.
Kubwibyo, iyi mpapuro ivuga muri make imikoranire iri hagati yicyayi nibice bikora byimikorere hamwe nindabyo mumyaka myinshi - ubuzima bwimikorere - Ibara ryinyamanswa - Ibice bya Wattabol - Ibice bya Wattabolle "

01
Umubano hagati ya flora yinyama na mu rugo rwabantu
Hamwe n'ibidukikije bishyushye kandi bitarondoreka amara, mikorobe irashobora gukura no kubyara mu mara ya muntu, aricyo gice kidasanzwe cyumubiri wumuntu. Microbiota yatwarwa numubiri wumuntu irashobora gutera imbere muburyo bwo guteza imbere umubiri wumuntu, kandi ukomeze gushikama nigihe gito ukuze kugeza gupfa.
Flora yinyama irashobora kugira ingaruka zikomeye kubudahangarwa bwabantu, metabolism na sisitemu yimitsi binyuze muri metabolite yayo, nkabanjirije urunigi rugufi (SCFAS). Mu mara y'abantu bakuru bakuze, bagiteri hamwe nibara ryinshi, ibaruramari rirenga 90% ya Flora yinyamanswa, ikurikiwe na Actinobacteria, Protebicteria, Verrucomichabia nibindi.
Mikorobe zitandukanye mumara mu nama runaka, igabanya kandi ishingiye kuri buriwese, kugirango ukomeze kuringaniza mu rugo rwinyamanswa. Guhangayikishwa no mu mutwe, kurya, antibiyotike, phicmalique phi n'ibindi bintu bizasenya impirimbanyi zihamye, kandi ku rugero runaka, ndetse n'izindi ndwara zigenda zingana, n'indwara zo mu mazi n'ibino.
Indyo nigice cyingenzi kigira ingaruka kuri flora yinyama. Indyo nziza (nka fibre ndende, prebiyotike, ibibi) bizateza imbere bagiteri yingirakamaro, nko kwiyongera kwa lactobacill hamwe no kuzamura insuline, kugirango nzengure kwiyumvisha no guteza imbere ubuzima bwakira. Indyo yuzuye (nk'isukari ndende n'indyo ndende ya calorie) izahindura imiterere y'inyamanswa kandi yongere igipimo cya bagiteri mbi cyane, mu gihe bagiteri mbi cyane, kandi biganisha ku mugako, no guswera ndetse no kugoreka kandi ndetse no kugota inyongera.
Kubwibyo, indyo ifite akamaro gakomeye yo gukomeza no guhinduranya urugo rwamahoto yinyamanswa yinyamanswa, ifitanye isano itaziguye nubuzima bwabakiriye.

02

Kugenga icyayi nibice bigize imikorere kuri flora yinyama
Kugeza ubu, hari ibice birenga 700 bizwi mu cyayi, harimo polyphenol y'icyayi, icyayi polypaccharides, THEYIINE, cafeyine nibindi. Ubushakashatsi bwerekanye ko icyayi n'ibigize imikorere yacyo bigira uruhare runini mu buryo butandukanye bwa Flora y'amara, harimo kuzamura imikurire y'inyamanswa nka NEDRURMARIYACECECE na EnterubaCter.
1. Kugenzura icyayi kuri flora yinda
Muri cilite ya colitis yatewe na sodium ya dextran yagaragaye ko ifite ingaruka za plobiotic, ishobora kongera itandukaniro ryinyamanswa muri colitis, rishobora kongera indorerezi zuburakari muri colidis muri colitis imbibi zishobora kwangiza no kongera ubwinshi bwa bagiteri zishobora kwangiza.

Huang et al. Basanze kuvura icyayi cya pu'er birashobora kugabanya cyane gutwika amara bitemejwe na sodium ya dextran sodium; Muri icyo gihe, gufata icyayi cya PU'ER kirashobora kugabanya byinshi bya bagiteri, cya Sinzimari. Ubushakashatsi bwa bagiteri ya fecal bwagaragaje ko icyayi cya Pu'er kirashobora guteza imbere colidis byatewe na dextate ya sodium ya dexran yahinduye ubusumbane bwa flora yinyamanswa. Uku kunoza birashobora kubera ubwiyongere bwa SCFAS muri Ceuse Cecum no gukora ku byakirwa by'ubukorikori bwa peroxisome ya makiyako γ kwiyongera. Ubu bushakashatsi bwerekana ko icyayi gifite ibikorwa bya prebiotic, kandi imikorere yubuzima yicyayi yitirirwa byibuze mubice byamabwiriza yamakuru yinyamanswa.

2. Kugenga icyayi polyphel kuri flora yinyama
Zhu et al yasanze intera y'icyayi ya Fuzhuan irashobora kugabanya cyane ubusumbane bw'imyororo y'inyama z'imbeba zatewe n'imiterere y'imishinga y'amara, mu rwego rwo kongera indyo yuzuye mikorobe, ndetse no kongera ubunini bwa mikorobe y'amara, ndetse no kongera ubunini bw'indahiro mikorobe y'amarangi Ubushakashatsi bwa fecalis Fashime, kandi ubushakashatsi bwa bagiteri bwa fecal bwerekanye ko hagaragaye ingaruka zo guta ibiro bya polypaan icyayi cya Fuzhuan kijyanye na flora yinyama. Wu et al. Byagaragaye ko mu cyitegererezo cya colidis cyatewe na dexran sodium sulfate, ingaruka zigabanya epigallocatechin jollalate (egcg) kuri colidis zigerwaho no kugenzura ibimera by'inda. Egcg irashobora kunoza neza ubwinshi bwa SCFAS itanga mikorobe, nka ackermann na lactobacillus. Ingaruka ya prebiotic yicyayi polphenol irashobora kugabanya ubusumbane bwa flora yinyama iterwa nibintu bibi. Nubwo Capiteri yihariye ya bagiteri yagengwaga nisoko zitandukanye za polyphenol zishobora kuba zitandukanye, ntagushidikanya ko imikorere yubuzima isafubumwe ifitanye isano rya bugufi na flora yinyama.
3. Kugenga icyayi Polysaccharide kuri flora yinyama
Icyayi Polsacchardes birashobora kongera ubudasa bwurukoza. Yabonetse mu mara ya diyabete y'imbeba y'imboga zirashobora kongera umubare wa SCFACCHASMS, nka Lachnospira, Visvallis na Rosseli, hanyuma utezimbere Glucose na Lipid Metabolism. Muri icyo gihe, muri colitide ya colidis yatewe na sodium ya dextran yatewe no kuzamura imikurire ya bandaro, ishobora kugabanya urwego rwa LP hamwe na Plasma, kuzamura imikorere ya bariyeri epirinter kandi ibuza gutwika amara na sisitemu. Kubwibyo, icyayi polsacharide gishobora guteza imbere imisoro ishobora kuba ingirakamaro nka SCFAS no kubuza imikurire ya LPS itanga mikorobe nibigize imiterere yinyamanswa no gukomeza inzu yinyamanswa yumurabyo.
4.
Icyayi Saponin, uzwi kandi nka Icyayi Saponin, ni ubwoko bwa glycoside ibigo bifite imiterere yimiterere yakuwe mu mbuto. Ifite uburemere bunini bwa molecular, polarity ikomeye kandi biroroshye gusenya mumazi. Li Yu nabandi bagaburira abana b'intama bafite icyayi saponin. Ibisubizo by'isesengura ry'amara byerekanwe ko kuri bagiteri ugereranije zijyanye no kuzamura ubudahangarwa bw'umubiri n'ubushobozi bwo gupfobya byiyongereye cyane, mu gihe bagiteri ugereranije zijyanye no kwandura umubiri zagabanutse cyane. Kubwibyo, saponin yicyayi ifite ingaruka nziza mumaso yintama. Gutabara icyayi Saponin birashobora kongera isura itandukanye yinyama, kandi kuzamura ubuhanga bwinyamanswa, no kuzamura ubudahangarwa nubushobozi bwo gusuzugura umubiri.
Byongeye kandi, ibintu nyamukuru bigize imikorere yicyaya kandi birimo tyanine na cafeyine. Ariko, kubera ibinyabuzima birebire bya theanaine, cafeyine nibindi bigize bikora, ingenzi byarangiye ahanini mbere yo kugera amara, mugihe inyama zumuraro zikwirakwizwa cyane mumara manini. Kubwibyo, imikoranire hagati yabo na flora yinyama ntisobanutse.

03
Icyayi nibigize imikorere yacyo bigenga ibimera
Uburyo bushoboka bugira ingaruka kubuzima bwakira
Lipinski n'abandi bemeza ko ibinyabuzima bikomoka muri rusange bifite ibiranga bikurikira: (1) Uburemere bwa moleculand ya molecular> 500, LogP> 5; (2) Umubare wa - Oh cyangwa - NH mu kigo ni ≥ 5; .
Ariko, ubushakashatsi bwerekanye ko ibyo bigize bishobora guhinduka intungamubiri za flora yinyama. Ku ruhande rumwe, ibyo bintu bitavumbuwe birashobora guteshwa agaciro mubintu bito bikora bya molecular nka SCFAS kugirango ishishikarize abantu kandi igakoreshe hamwe no kwitabira ingano yinyama. Ku rundi ruhande, ibintu birashobora kandi kugenga ingano yinyamanswa, kuzamura imikurire yimisoro ifatika nka SCFAS kandi bibuza imikurire ya mikorobe yangiza nka lps.
Koropatkin et al yasanze inyamanswa zo mu mara zishobora kurwanya polysackarae muri icyayi muri scbaletites yiganjemo scfas binyuze mu gutesha agaciro kabiri. Byongeye kandi, icyayi polyphel mu mara kidashizwe mu mara kandi gikoreshwa buhoro buhoro mu bigo byihuta cyane mu bigo by'inyamanswa, kugira ngo yerekane ibikorwa byo hejuru ku mubiri no gukoresha.
Umubare munini w'ubushakashatsi wemeje ko icyayi n'ibigize ibikorwa byayo bikora cyane cyane mu maraso no kubungabunga icoribile y'inyamanswa no gukoresha mikorobe y'imiterere no gukoresha mikoroli, kandi bikagira uruhare rwose ku buzima bw'icyayi n'imikorere yacyo. Guhuzwa nisesengura ryibitabo, uburyo bw'icyayi, ibice byayo bikora kandi bigize flora yo mu mara bishobora kugaragara cyane mubiri mu bintu bitatu bikurikira.
1. Icyayi nibigize imikorere yacyo - Flora yinyama - SCFAS - Uburyo bwo kugenzura ubuzima bwakiriye
Geno zigendanwa zinyamanswa zirenze inshuro 150 zirenze jance yabantu. Uruganda rutandukanye rwa mikorobe rutuma enzymes hamwe ninzira yibinyabuzima ya metaboocial ko uwakiriye adafite, kandi arashobora gushiramo imibereho minini yumuntu urwaye kugirango uhindure polyssaccharide na SCFAS.
SCFAS ikorwa na fermentation no guhindura ibiryo bidashidikanywaho mumara. Nicyo metabolite nyamukuru ya mikorobe yimpera yamara, ahanini harimo acide acide, aside proionic na aside ya aside. SCFAS ifatwa nkaho ijyanye na glucose na lipid metabolism, gutwika amara, inzangano zumuraro, kugenda kwanda hamwe nibikorwa byubudahangarwa. Muri colilis ya colitis yatewe na sodium idasanzwe, icyayi birashobora kongera ubwinshi bwa scfas ikora mikorobe kandi yongera ibikubiye muri acide ya acide, aside prointic mumyandikire. Icyayi cya Pu'er Polysaccharde gishobora kugirirwa ikigereranyo cyane, guteza imbere imikurire ya SCFAS itanga mikorobe no kongera ibiri muri SCFAS mumyanda yimbeba. Bisa na Polysaccharides, gufata polyphenol yicyayi birashobora kandi kongera ibitekerezo bya SCFAS no guteza imbere imikurire ya SCFAS itanga mikorobe. Muri icyo gihe, wang et al yasanze gufata muri Terubicin bishobora kongera ubwinshi bw'amara atanga SCFAS, ashyiraho ishingwa rya SCFAS, cyane cyane igenamigambi rya acide ribitashye kandi ritezimbere ikibazo cyo kuriganya cyatewe n'indyo yuzuye.
Kubwibyo, icyayi nibigize imikorere byayo birashobora guteza imbere imikurire no kubyara bya SCFAS bitanga mikorobe mu kugenzura ibiraku byumubiri, kugirango byongere ibikubiye muri SCFAS mumubiri no gucuranga imikorere yubuzima.

2. Icyayi nibigize imikorere yacyo - Ibara ry'amara - Bas - Uburyo bwo kugenzura ubuzima bwakiriye
Bile acide (bas) nubundi buryo bwimiterere yingaruka nziza kubuzima bwabantu, bukaba byanditswe na hepatocytes. Acide y'ibanze acide mu mwijima uhurira na taurine na glycine kandi basohozwa mu mara. Noneho urukurikirane rwibisubizo nka dehydroloxry, isomerization itandukanye nindaya bibaye mugikorwa cyamabara yinyama, amaherezo acide yipiganwa. Kubwibyo, inyama zumura zigira uruhare runini muri metabolism ya bas.
Byongeye kandi, impinduka za bas nazo zifitanye isano rya bugufi na glucose na lipabolism, indorerwamo yintara nubutaka. Ubushakashatsi bwerekanye ko icyayi cya Pu'er na Therownin burashobora kugabanya cholesterol na lipide ibuza imishinga ijyanye na mikorobe yamashanyarazi (bsh) kandi yongera urwego rwa ILEAL FIIL. Binyuze mu micungire ya EGCG na cafeyine, zhu et al. Habonetse uruhare rw'icyayi mu kugabanya ibinure no gutakaza ibiro bishobora kuba kubera ko Egcg na Cafeyine bishobora kunoza imvugo ya bile Sacine.
Kubwibyo, icyayi nibigize imikorere yacyo birashobora kugenga imikurire ya mikorobe ya mikoroguro yas, hanyuma uhindure ikidendezi cya acide
3. Icyayi nibigize imikorere yacyo - Ibara ry'amara - Ibindi Byumuhanda Metabolite - Uburyo bwo kugenzura ubuzima bwakiriwe
Lps izwi kandi nka endotoxin, nigice cyo hanze cyurukuta rwa selile ya bagiteri mbi. Ubushakashatsi bwerekanye ko ikibazo cya flora yinda kizatera ibyangiritse kuri bariyeri yimbeho, lps yinjira mu kuzenguruka amara, lps yinjira kuzenguruka kwakira, hanyuma biganisha ku rukurikirane rwibitekerezo byaka. Zuo Gaolong et al. Habonetse icyayi cya Fuzhuan cyane cyagabanije urwego rwa Serum Lps mu mbaraga ziterwa nindwara zidasanzwe, hamwe na bagiteri mbisi yintoki zamabara yagabanutse cyane. Byari byiza ko icyayi cya Fuzhuan gishobora kubuza gukura kwa bagiteri mbisi itera lps mumara.
Byongeye kandi, icyayi n'ibigize ibikorwa byayo birashobora kandi kugenzura ibikubiye muri Metabolites zitandukanye zinyuranye n'ikorananga, vitamine K2 na Retabolism na Lipid Metabolism na Lipid metabolism no kurinda amagufwa.

04
Umwanzuro
Nkimwe mubinyobwa bizwi cyane kwisi, imikorere yubuzima yicyayi yamaze kwibaga cyane mu tugari, inyamaswa ndetse numubiri wumuntu. Kera, akenshi byatekerezwaga ko imikorere yubuzima yicyayi igabogamye cyane, anti-insimatiyo, kurwanya oki-okiside nibindi.
Mu myaka yashize, ubushakashatsi bwurubuga rwinyama tugiye kwitabwaho buhoro buhoro. Kuva ku burwayi bwa mbere "kwakira amara mu mara" kuri ubu "kwakira inyama z'inyamanswa metabolites", birasuzugura isano iri hagati yindwara na flora yinyama. Ariko, kuri ubu, ubushakashatsi ku mategeko y'icyayi n'imikorere yarwo ku mubano w'inyama n'akagari kangiza, mu gihe habaye imikurire ya bagiteri mbi, mu gihe habaye imikurire ya bagiteri zangiza, mu gihe habaye imikurire ya bagiteri.
Kubwibyo, ukurikije incamake yubushakashatsi bwa vuba, iyi mpapuro ikora igitekerezo nyamukuru cya "icyayi nibice byimikorere - ubuzima bwakira", kugirango ntange ibitekerezo bishya kugirango ukoreshe imikorere yubuzima bwicyayi nibice byimikorere.
Kubera uburyo budasobanutse bwa "icyayi nibigize imikorere yacyo - Ibara ryinyama - Ubuzima bwa Watstan", Iterambere ryubuzima ", Iterambere ryiterambere ryicyayi nibice byimikorere nkuko ibyari bigarukira. Mu myaka yashize, "Igisubizo cyibiyobyabwenge kugiti cye" cyagaragaye ko gifitanye isano cyane nitandukaniro ryinyamanswa. Muri icyo gihe, hamwe n'icyifuzo cy'ibitekerezo by '"imiti isobanura imirire" na "ibiryo by'ukuri", ibisabwa byinshi bishyirwaho mu rwego rwo gusobanura isano iri hagati y "icyayi n'ibikoresho byayo - ubuzima bw'intara". Mubushakashatsi buzaza, abashakashatsi bagomba kurushaho gusobanura imikoranire hagati yicyayi nibice byayo bikora hamwe nubufasha bwinyamanswa ifatika, nko guhuza amatsinda menshi (nka Macrorolome na metabolome). Imikorere yubuzima yicyayi nibice bigize imikorere byarasenyutse ukoresheje tekinike yo kwigunga no kweza imbeba zumurasho hamwe nimbeba mbi. Nubwo uburyo bwicyayi nibigize imikorere yacyo bugenga ibirabyo byirangi bitagaragara, ntagushidikanya ko ingaruka zishinzwe imirimo nibigize imikorere yinyama naho imikorere yubuzima.