Icyayi cy'umukara, cyuzuye ferment, nicyayi gikoreshwa cyane kwisi. Mugihe itunganijwe, igomba gukama, kuzunguruka no gusembura, ibyo bikaba bitera reaction ya biohimiki yingingo yibintu biri mumababi yicyayi kandi amaherezo ikabyara uburyohe budasanzwe ningaruka zubuzima. Vuba aha, itsinda ry’ubushakashatsi riyobowe na Prof. WANG Yuefei wo mu Ishuri Rikuru ry’Ubuhinzi n’ibinyabuzima, kaminuza ya Zhejiang, ryateye intambwe ishimishije mu bijyanye n’ubuziranenge n’imikorere y’icyayi cyirabura.

Bakoresheje isuzuma ryibyumviro hamwe na metabolomics kugirango basesengure ingaruka ziterwa nuburyo butandukanye bwo gutunganya ku cyayi cyirabura cya Zijuan gihindagurika kandi kidahindagurika, itsinda ryasanze aside ya fenylacetike na glutamine bifitanye isano cyane nimpumuro nziza nuburyohe bwicyayi cyirabura cya Zijuan. bityo gutanga ibisobanuro byerekana uburyo bwiza bwo gutunganya icyayi cyirabura cya Zijuan (Zhao et al., LWT -Ubumenyi bwibiryo nikoranabuhanga, 2020). Mu bushakashatsi bwakurikiyeho, basanze ko umwuka wa ogisijeni ushobora gutera catechine, flavonoide glycoside na acide ya fenolike, na okiside ya catechine bishobora kwihutisha iyangirika rya aside amine kugira ngo bibe aldehydes ihindagurika kandi bigatera okiside ya acide ya fenolike, bityo bikagabanya ubukana n’uburakari ndetse no kongera ubukana bwa umami , itanga ubushishozi bushya bwo gukora icyayi cyirabura. Ubu bushakashatsi bwakozwe bwasohotse mu kiganiro cyiswe “Fermentation ikungahaye kuri Oxygene ituma uburyohe bw'icyayi cy'umukara bugabanya metabolite ikaze kandi ikabije” mu kinyamakuruUbushakashatsi ku biribwa mpuzamahangaNyakanga, 2021.

Imihindagurikire ya metabolite idafite imbaraga mugihe cyo kuyitunganya igira ingaruka kumikorere myiza yubuzima bwicyayi cyirabura. Mu Gushyingo 2021, itsinda ryasohoye ingingo ifunguye yiswe “Guhindura metabolite ya Nonvolatile mu gihe cyo gutunganya icyayi cyirabura cya Zijuan bigira ingaruka ku bushobozi bwo kurinda HOECs zanduye nikotine” mu kinyamakuruIbiryo & Imikorere. Ubu bushakashatsi bwerekanye ko leucine, isoleucine, na tirozine aribyo bicuruzwa nyamukuru bya hydrolysis mugihe cyumye, na theaflavin-3-gallate (TF-3-G), theaflavin-3'-gallate (TF-3'-G) na theaflavin-3 , 3'-gallate (TFDG) byakozwe cyane cyane mugihe cyo kuzunguruka. Byongeye kandi, okiside ya flavonoide glycoside, catechine na catericine dimeric yabayeho mugihe cya fermentation. Mugihe cyo gukama, aside amine ihinduka cyane. Ihinduka rya theaflavins, acide amine na glycoside ya flavonoide yagize ingaruka zikomeye mukurwanya icyayi cyirabura cya Zijuan cyatewe na nikotine iterwa na nikotine yatewe na selile epithelia selile, byerekana ko gutunganyiriza ibintu byihariye bikora no kuzamura imikorere yihariye yicyayi cyirabura mugutezimbere uburyo bwo gukora icyayi cyirabura gishobora kuba igitekerezo cyubwenge bwo gutunganya icyayi.

Ukuboza 2021, iryo tsinda ryasohoye indi ngingo yise “Icyayi cy'umukara kigabanya cyane ibikomere byatewe n'ibihaha byatewe na Gut-Lung Axis mu mbeba” muriIkinyamakuru cyaUbuhinzi n'Ubuhinzi. Ubu bushakashatsi bwerekanye ko PM (uduce duto) -imbeba zagaragajwe zagaragaje imbaraga za okiside hamwe n’umuriro mu bihaha, ibyo bikaba byashoboraga kugabanuka cyane no gufata buri munsi icyayi cyirabura cya Zijuan mu buryo bushingiye ku kwibanda. Igishimishije, ibice byombi bya Ethanol-soluble (ES) hamwe na Ethanol imvura igwa (EP) byagaragaje ingaruka nziza kurenza izo TI. Byongeye kandi, transplantation ya microbiota fecal (FMT) yerekanye ko microbiota yo munda yahinduwe mu buryo butandukanye na TI kandi ibice byayo byashoboye gukuraho mu buryo butaziguye imvune yatewe na PM. Byongeyeho ,.Lachnospiraceae_NK4A136_itsindabirashobora kuba intangiriro ya mikorobe igira uruhare mukurinda EP. Wang yagize ati: "Ibi bisubizo byerekanye ko gufata buri munsi icyayi cy'umukara n'ibice byayo, cyane cyane EP, bishobora kugabanya ibikomere byatewe na PM binyuze mu nda y'ibihaha mu mbeba, bityo bigatanga ibitekerezo ku mikorere y'ubuzima bw'icyayi cy'umukara".