Zotsatira zotsutsa-kutupa ndi detoxifying wa tiyi zalembedwa kale Shennong herbal classic. Ndi chitukuko cha sayansi ndi luso lamakono, anthu amalipira ndalama zambiri
komanso chidwi kwambiri ndi ntchito yazaumoyo ya tiyi. Tiyi ndi wolemera mu tiyi polyphenols, tiyi polysaccharides, theanine, tiyi kapena khofi ndi zigawo zina zinchito. Ili ndi kuthekera kopewa kunenepa kwambiri, shuga, kutupa kosatha ndi matenda ena.
Zomera za m'matumbo zimatengedwa ngati "chiwalo cha metabolic" chofunikira komanso "chiwalo cha endocrine", chomwe chimapangidwa ndi tizilombo tating'onoting'ono ta 100trillion m'matumbo. Zomera za m'mimba zimagwirizana kwambiri ndi kupezeka kwa kunenepa kwambiri, shuga, matenda oopsa ndi matenda ena.
M'zaka zaposachedwa, kafukufuku wochulukirachulukira apeza kuti chithandizo chamankhwala chapadera cha tiyi chikhoza kukhala chifukwa cha kugwirizana pakati pa tiyi, zigawo zogwira ntchito ndi zomera zam'mimba. Zolemba zambiri zatsimikizira kuti tiyi polyphenols yokhala ndi bioavailability yochepa imatha kuyamwa ndikugwiritsidwa ntchito ndi tizilombo tating'onoting'ono m'matumbo akulu, zomwe zimapangitsa kuti pakhale thanzi. Komabe, njira yolumikizirana pakati pa tiyi ndi zomera zam'mimba sizidziwika bwino. Kaya ndi zotsatira zachindunji za ma metabolites a tiyi omwe amagwira ntchito ndi tiyi ndi kutenga nawo gawo kwa tizilombo tating'onoting'ono, kapena zotsatira za tiyi zomwe zimalimbikitsa kukula kwa tizilombo tating'onoting'ono tating'ono m'matumbo kuti tipange ma metabolites opindulitsa.
Chifukwa chake, pepalali limafotokoza mwachidule za mgwirizano pakati pa tiyi ndi zigawo zake zogwira ntchito ndi zomera zam'mimba kunyumba ndi kunja kwazaka zaposachedwa, ndikuphatikiza njira zowongolera za "tiyi ndi zigawo zake zogwira ntchito - m'matumbo am'mimba - metabolites m'matumbo - thanzi la alendo", kuti perekani malingaliro atsopano pophunzira za thanzi la tiyi ndi zigawo zake zogwira ntchito.

01
Kugwirizana pakati pa zomera zam'mimba ndi homeostasis yaumunthu
Ndi malo otentha ndi osagawanika m'matumbo a munthu, tizilombo toyambitsa matenda timatha kukula ndi kuberekana m'matumbo a munthu, omwe ndi gawo losalekanitsidwa la thupi la munthu. Ma microbiota omwe amanyamulidwa ndi thupi la munthu amatha kukula limodzi ndi kukula kwa thupi la munthu, ndikukhalabe okhazikika pakanthawi komanso kusiyanasiyana kwake akakula mpaka imfa.
Zomera za m'matumbo zimatha kukhudza kwambiri chitetezo chamunthu, kagayidwe kachakudya komanso dongosolo lamanjenje kudzera m'ma metabolites ake olemera, monga ma chain chain fatty acids (SCFAs). M'matumbo a anthu akuluakulu omwe ali ndi thanzi labwino, Bacteroidetes ndi Firmicutes ndi zomera zomwe zimakhala zazikulu kwambiri, zomwe zimakhala zoposa 90% za zomera zonse za m'mimba, zotsatiridwa ndi Actinobacteria, Proteobacteria, verrucomicrobia ndi zina zotero.
Tizilombo tosiyanasiyana m'matumbo timaphatikizana mosiyanasiyana, timaletsa ndi kudalirana, kuti tisunge matumbo am'matumbo homeostasis. Kupsinjika kwamalingaliro, chizolowezi chodya, maantibayotiki, pH yamatumbo osakhazikika ndi zinthu zina zimatha kuwononga matumbo okhazikika, kumayambitsa kusalinganika kwamatumbo am'mimba, ndipo pamlingo wina, kumayambitsa matenda a metabolic, kutupa, komanso matenda ena okhudzana nawo. , monga matenda a m'mimba, matenda a ubongo ndi zina zotero.
Zakudya ndiye chinthu chofunikira kwambiri chomwe chimakhudza zomera zam'mimba. Zakudya zopatsa thanzi (monga ulusi wambiri wamafuta, prebiotics, etc.) zidzalimbikitsa kulimbikitsa mabakiteriya opindulitsa, monga kuchuluka kwa Lactobacillus ndi Bifidobacterium omwe amapanga SCFAs, kuti apititse patsogolo chidwi cha insulin ndikulimbikitsa thanzi la alendo. Zakudya zopanda thanzi (monga shuga wambiri ndi zakudya zama calorie ambiri) zidzasintha mapangidwe a zomera za m'mimba ndikuwonjezera chiwerengero cha mabakiteriya a gram-negative, pamene mabakiteriya ambiri a gram-negative adzalimbikitsa kupanga lipopolysaccharide (LPS), kuonjezera matumbo a m'mimba, ndi kuyambitsa kunenepa kwambiri, kutupa komanso endotoxemia.
Chifukwa chake, zakudya ndizofunika kwambiri pakusunga ndi kupanga homeostasis yamatumbo am'mimba, omwe amagwirizana mwachindunji ndi thanzi la wolandirayo.

02

Kuwongolera tiyi ndi zigawo zake zogwira ntchito pamaluwa a m'mimba
Pakalipano, pali mankhwala oposa 700 odziwika mu tiyi, kuphatikizapo tiyi polyphenols, tiyi polysaccharides, theanine, caffeine ndi zina zotero. Kafukufuku wasonyeza kuti tiyi ndi zigawo zake zogwira ntchito zimagwira ntchito yofunika kwambiri pakusiyanasiyana kwa zomera za m'mimba za anthu, kuphatikizapo kulimbikitsa kukula kwa ma probiotics monga akkermansia, bifidobacteria ndi Roseburia, ndikulepheretsa kukula kwa mabakiteriya owopsa monga Enterobacteriaceae ndi Helicobacter.
1. Malamulo a tiyi pa zomera za m'mimba
Muchitsanzo cha colitis choyambitsidwa ndi dextran sodium sulfate, tiyi asanu ndi limodzi atsimikiziridwa kuti ali ndi zotsatira za prebiotic, zomwe zingawonjezere kwambiri mitundu yosiyanasiyana ya m'mimba mu mbewa za colitis, kuchepetsa kuchuluka kwa mabakiteriya omwe angakhale ovulaza ndikuwonjezera kuchuluka kwa mabakiteriya omwe angakhale opindulitsa.

Huang ndi al. Anapeza kuti chithandizo chothandizira tiyi cha Pu'er chingachepetse kwambiri kutupa kwa m'mimba komwe kumabwera chifukwa cha dextran sodium sulfate; Panthawi imodzimodziyo, chithandizo cha tiyi cha Pu'er chingachepetse kuchuluka kwa mabakiteriya omwe angakhale ovulaza Spirillum, cyanobacteria ndi Enterobacteriaceae, ndikulimbikitsa kuwonjezeka kwa kuchuluka kwa mabakiteriya opindulitsa Ackermann, Lactobacillus, muribaculum ndi ruminococcaceae ucg-014. Kuyesa kwa mabakiteriya a chimbudzi kunatsimikiziranso kuti tiyi ya Pu'er imatha kusintha colitis yoyambitsidwa ndi dextran sodium sulfate posintha kusalinganika kwa zomera zam'mimba. Kusintha kumeneku kungakhale chifukwa cha kuchuluka kwa ma SCFAs mu mbewa cecum ndi kutsegula kwa zolandilira ndi colonic peroxisome proliferators γ Kuwonjezeka kwa mawu. Kafukufukuyu akuwonetsa kuti tiyi ali ndi zochita za prebiotic, ndipo thanzi la tiyi limadziwika kuti ndi gawo limodzi la kayendetsedwe kake ka m'matumbo.

2. Kuwongolera tiyi polyphenols pa zomera za m'mimba
Zhu et al adapeza kuti kulowererapo kwa Tea ya Fuzhuan Tea Polyphenol kumatha kuchepetsa kwambiri kusalinganika kwa zomera zam'mimba mu makoswe omwe amachititsidwa ndi zakudya zamafuta ambiri, kukulitsa kusiyanasiyana kwamaluwa a m'matumbo, kuchepetsa chiŵerengero cha Firmicutes / Bacteroidetes, ndikuwonjezera kwambiri kuchuluka kwapakatikati. tizilombo toyambitsa matenda, kuphatikizapo akkermansia muciniphila, alloprevotella Bacteroides ndi faecalis baculum, komanso kuyesa kwa mabakiteriya a fecal kunatsimikiziranso kuti kuchepa kwa thupi la Fuzhuan Tea polyphenols kumagwirizana mwachindunji ndi zomera zam'mimba. Wu et al. Zatsimikiziridwa kuti mu chitsanzo cha colitis choyambitsidwa ndi dextran sodium sulfate, kuchepetsa mphamvu ya epigallocatechin gallate (EGCG) pa colitis kumatheka poyang'anira zomera za m'mimba. EGCG imatha kusintha bwino kuchuluka kwa ma SCFA omwe amapanga tizilombo tating'onoting'ono, monga Ackermann ndi Lactobacillus. Mphamvu ya prebiotic ya tiyi ya polyphenols imatha kuchepetsa kusalinganika kwamaluwa a m'mimba chifukwa cha zovuta. Ngakhale takisi ya bakiteriya yomwe imayendetsedwa ndi magwero osiyanasiyana a tiyi ya polyphenols ikhoza kukhala yosiyana, palibe kukayika kuti ntchito yathanzi ya tiyi polyphenols imagwirizana kwambiri ndi zomera zam'mimba.
3. Malamulo a tiyi polysaccharide pa zomera za m'mimba
Ma polysaccharides a tiyi amatha kuonjezera mitundu yosiyanasiyana ya m'mimba. Zinapezeka m'matumbo a makoswe amtundu wa shuga kuti ma polysaccharides a tiyi amatha kuonjezera kuchuluka kwa ma SCFA omwe amapanga tizilombo tating'onoting'ono, monga lachnospira, victivallis ndi Rossella, kenako ndikuwongolera shuga ndi lipid metabolism. Panthawi imodzimodziyo, mu chitsanzo cha colitis choyambitsidwa ndi dextran sodium sulfate, tiyi ya polysaccharide inapezeka kuti imalimbikitsa kukula kwa Bacteroides, yomwe ingachepetse mlingo wa LPS mu ndowe ndi plasma, kupititsa patsogolo ntchito ya m'mimba epithelial chotchinga ndikulepheretsa matumbo ndi machitidwe. kutupa. Chifukwa chake, tiyi polysaccharide imatha kulimbikitsa kukula kwa tizilombo tating'onoting'ono tomwe tingapindule monga ma SCFAs ndikuletsa kukula kwa tizilombo toyambitsa matenda a LPS, kuti tipititse patsogolo kapangidwe ndi kapangidwe ka m'matumbo ndikusunga ma homeostasis amtundu wamatumbo amunthu.
4. Kuwongolera zigawo zina zogwira ntchito mu tiyi pa zomera za m'mimba
Tiyi ya saponin, yomwe imadziwikanso kuti saponin ya tiyi, ndi mtundu wamagulu a glycoside okhala ndi mawonekedwe ovuta otengedwa ku mbewu za tiyi. Ili ndi kulemera kwakukulu kwa maselo, polarity yamphamvu ndipo ndi yosavuta kusungunuka m'madzi. Li Yu ndi ena anadyetsa ana a nkhosa oyamwa ndi tiyi wa saponin. Zotsatira za kusanthula kwa zomera za m'mimba zimasonyeza kuti kuchuluka kwa mabakiteriya opindulitsa okhudzana ndi kupititsa patsogolo chitetezo cha thupi ndi kugaya chakudya chinawonjezeka kwambiri, pamene kuchuluka kwa mabakiteriya ovulaza omwe amagwirizana ndi matenda a thupi kunachepa kwambiri. Chifukwa chake, tiyi saponin imakhala ndi zotsatira zabwino pamatumbo am'mimba a nkhosa. Kulowetsedwa kwa tiyi saponin kumatha kukulitsa kusiyanasiyana kwamaluwa am'mimba, kukonza matumbo am'mimba, ndikuwonjezera chitetezo chamthupi komanso kugaya chakudya.
Kuphatikiza apo, zigawo zikuluzikulu zogwira ntchito mu tiyi zimaphatikizaponso theanine ndi caffeine. Komabe, chifukwa cha kuchuluka kwa bioavailability wa theanine, caffeine ndi zigawo zina zogwira ntchito, kuyamwa kwatsirizidwa kwenikweni kusanafike m'matumbo akuluakulu, pamene zomera za m'mimba zimagawidwa makamaka m'matumbo akuluakulu. Choncho, kugwirizana pakati pawo ndi zomera za m'mimba sikumveka bwino.

03
Tiyi ndi zigawo zake zogwira ntchito zimayang'anira zomera za m'mimba
Njira zotheka zomwe zimakhudza thanzi la alendo
Lipinski ndi ena amakhulupirira kuti mankhwala okhala ndi bioavailability otsika amakhala ndi makhalidwe awa: (1) pawiri molecular kulemera> 500, logP> 5; (2) Kuchuluka kwa - O kapena - NH mu pawiri ndi ≥ 5; (3) Gulu la N kapena gulu la O lomwe lingathe kupanga mgwirizano wa haidrojeni mu chigawocho ndi ≥ 10. Zambiri zomwe zimagwira ntchito mu tiyi, monga theaflavin, thearubin, tiyi polysaccharide ndi mankhwala ena a macromolecular, ndi ovuta kuti alowe mwachindunji ndi thupi la munthu. chifukwa ali ndi zonse kapena gawo lazomwe zili pamwambapa.
Komabe, kafukufuku wasonyeza kuti mankhwalawa akhoza kukhala zakudya za m'matumbo. Kumbali imodzi, zinthu zomwe sizinayamwidwezi zitha kusinthidwa kukhala tinthu tating'ono tating'ono tating'onoting'ono tating'onoting'ono monga ma SCFAs kuti amwe anthu ndikugwiritsa ntchito mothandizidwa ndi zomera zam'mimba. Kumbali inayi, zinthuzi zimathanso kuyendetsa m'mimba, kulimbikitsa kukula kwa tizilombo toyambitsa matenda timene timapanga zinthu monga ma SCFAs ndikuletsa kukula kwa tizilombo toyambitsa matenda timene timapanga zinthu monga LPS.
Koropatkin et al adapeza kuti zomera za m'matumbo zimatha kusokoneza ma polysaccharides mu tiyi kukhala metabolites yachiwiri yomwe imayendetsedwa ndi SCFAs kudzera pakuwonongeka koyambirira komanso kuwonongeka kwachiwiri. Kuphatikiza apo, tiyi polyphenols m'matumbo, yomwe simalowetsedwa mwachindunji ndikugwiritsidwa ntchito ndi thupi la munthu nthawi zambiri imatha kusinthidwa pang'onopang'ono kukhala mankhwala onunkhira, ma phenolic acid ndi zinthu zina zomwe zimagwira m'matumbo am'mimba, kuti ziwonetsetse magwiridwe antchito apamwamba a thupi la munthu. ndi kugwiritsa ntchito.
Kafukufuku wambiri watsimikizira kuti tiyi ndi zigawo zake zimagwira ntchito makamaka zimayang'anira matumbo a m'mimba mwa kusunga matumbo osiyanasiyana, kulimbikitsa kukula kwa mabakiteriya opindulitsa ndikuletsa mabakiteriya owopsa, kuti azitha kuyang'anira ma metabolites ang'onoang'ono kuti mayamwidwe ndi magwiritsidwe ntchito a anthu, ndikusewera kwathunthu. ku thanzi labwino la tiyi ndi zigawo zake zogwira ntchito. Kuphatikizana ndi kusanthula mabuku, makina a tiyi, zigawo zake zogwirira ntchito ndi zomera za m'mimba zomwe zimakhudza thanzi la alendo zikhoza kuwonetsedwa makamaka muzinthu zitatu zotsatirazi.
1. Tiyi ndi zigawo zake zogwirira ntchito - zomera za m'mimba - SCFAs - njira zoyendetsera thanzi labwino
Majini a zomera za m'matumbo ndi apamwamba nthawi 150 kuposa majini aumunthu. Kusiyanasiyana kwa ma genetic kwa tizilombo tating'onoting'ono kumapangitsa kukhala ndi ma enzymes ndi njira za biochemical metabolic zomwe wolandirayo alibe, ndipo amatha kuyika ma enzymes ambiri omwe thupi la munthu limasowa kuti lisinthe ma polysaccharides kukhala monosaccharides ndi SCFAs.
Ma SCFA amapangidwa ndi kuwira ndi kusinthika kwa chakudya chosagawika m'matumbo. Ndi metabolite yayikulu ya tizilombo tating'onoting'ono tating'onoting'ono ta matumbo, makamaka acetic acid, propionic acid ndi butyric acid. Ma SCFA amaonedwa kuti ndi ogwirizana kwambiri ndi shuga ndi lipid metabolism, kutupa kwamatumbo, chotchinga m'matumbo, kuyenda kwa matumbo ndi chitetezo chamthupi. Mu mtundu wa colitis wopangidwa ndi dextran sodium sulfate, tiyi amatha kuchulukitsa kuchuluka kwa ma SCFA omwe amapanga tizilombo tating'onoting'ono m'matumbo a mbewa ndikuwonjezera zomwe zili mu acetic acid, propionic acid ndi butyric acid mu ndowe, kuti achepetse kutupa kwamatumbo. Pu'er tea polysaccharide imatha kuwongolera kwambiri zomera zam'mimba, kulimbikitsa kukula kwa ma SCFA omwe amapanga tizilombo tating'onoting'ono ndikuwonjezera zomwe zili mu SCFAs mu ndowe za mbewa. Mofanana ndi ma polysaccharides, kudya kwa tiyi polyphenols kumathanso kuonjezera kuchuluka kwa ma SCFA ndikulimbikitsa kukula kwa ma SCFA omwe amapanga tizilombo tating'onoting'ono. Panthawi imodzimodziyo, Wang et al adapeza kuti kudya kwa thearubicin kungathe kuonjezera kuchuluka kwa zomera za m'mimba zomwe zimapanga SCFAs, kulimbikitsa mapangidwe a SCFAs m'matumbo, makamaka mapangidwe a butyric acid, kulimbikitsa beige wamafuta oyera ndikuwongolera kutupa. matenda obwera chifukwa cha kudya kwambiri mafuta.
Chifukwa chake, tiyi ndi zigawo zake zogwira ntchito zimatha kulimbikitsa kukula ndi kubereka kwa ma SCFA omwe amapanga tizilombo tating'onoting'ono poyang'anira zomera zam'mimba, kuti awonjezere zomwe zili mu SCFAs m'thupi ndikusewera ntchito yofananira yaumoyo.

2. Tiyi ndi zigawo zake zogwirira ntchito - zomera za m'mimba - bas - ndondomeko yoyendetsera thanzi la alendo.
Bile acid (BAS) ndi mtundu wina wa mankhwala omwe ali ndi zotsatira zabwino pa thanzi la munthu, omwe amapangidwa ndi hepatocytes. Ma bile acid oyambilira opangidwa m'chiwindi amaphatikizana ndi taurine ndi glycine ndipo amatulutsidwa m'matumbo. Kenako zinthu zingapo monga dehydroxylation, kusiyanitsa isomerization ndi oxidation kumachitika pansi pa zochitika za m'matumbo, ndipo pamapeto pake ma acid achiwiri amapangidwa. Chifukwa chake, zomera zam'mimba zimagwira ntchito yofunika kwambiri mu metabolism ya bas.
Kuphatikiza apo, kusintha kwa BAS kumakhalanso kogwirizana kwambiri ndi shuga ndi lipid metabolism, chotchinga m'matumbo komanso kuchuluka kwa kutupa. Kafukufuku wawonetsa kuti tiyi ya Pu'er ndi theabrownin imatha kuchepetsa cholesterol ndi lipid poletsa tizilombo toyambitsa matenda okhudzana ndi bile salt hydrolase (BSH) ndikuwonjezera kuchuluka kwa bile acid. Kupyolera mu kuphatikiza kwa EGCG ndi caffeine, Zhu et al. Anapeza kuti ntchito ya tiyi kuchepetsa mafuta ndi kuwonda kungakhale chifukwa EGCG ndi tiyi kapena khofi akhoza kusintha mawu a bile saline lyase BSH jini ya zomera m'matumbo, kulimbikitsa kupanga non conjugated bile zidulo, kusintha bile acid dziwe, ndiyeno ziletsa kunenepa. chifukwa cha zakudya zokhala ndi mafuta ambiri.
Chifukwa chake, tiyi ndi zigawo zake zogwira ntchito zimatha kuwongolera kukula ndi kubereka kwa tizilombo tating'onoting'ono tomwe timagwirizana kwambiri ndi kagayidwe kake ka BAS, kenako ndikusintha dziwe la bile acid m'thupi, kuti lizigwira ntchito yotsitsa lipid-kuchepetsa komanso kuwonda.
3. Tiyi ndi zigawo zake zogwirira ntchito - zomera za m'mimba - ma metabolites ena a m'mimba - njira zoyendetsera thanzi labwino.
LPS, yomwe imadziwikanso kuti endotoxin, ndi gawo lakunja la khoma la cell la mabakiteriya a Gram-negative. Kafukufuku wasonyeza kuti kusokonezeka kwa zomera za m'mimba kungayambitse kuwonongeka kwa chotchinga cha m'mimba, LPS imalowa m'magazi, ndiyeno imayambitsa zochitika zambiri zotupa. Zuo Gaolong et al. Anapeza kuti Fuzhuan Tiyi kwambiri kuchepetsa mlingo wa seramu LPS mu makoswe ndi nonalcoholic mafuta chiwindi matenda, ndi chiwerengero cha mabakiteriya Gram-negative m'matumbo utachepa kwambiri. Zinanenedwanso kuti Tiyi ya Fuzhuan ikhoza kulepheretsa kukula kwa mabakiteriya a Gram-negative omwe amapanga LPS m'matumbo.
Kuphatikiza apo, tiyi ndi zigawo zake zogwira ntchito zimathanso kuwongolera zomwe zili mumitundu yosiyanasiyana yamatumbo am'mimba, monga mafuta odzaza mafuta, ma amino acid, vitamini K2 ndi zinthu zina, kuti azitha kuyendetsa shuga ndi lipid metabolism. ndi kuteteza mafupa.

04
Mapeto
Monga chakumwa chodziwika kwambiri padziko lonse lapansi, ntchito yathanzi ya tiyi yawerengedwa kwambiri m'maselo, nyama komanso ngakhale thupi la munthu. M'mbuyomu, nthawi zambiri zinkaganiziridwa kuti ntchito za thanzi la tiyi zinali makamaka kutsekereza, anti-inflammatory, anti-oxidation ndi zina zotero.
M'zaka zaposachedwapa, kafukufuku wa zomera m'matumbo pang'onopang'ono amakopa chidwi kwambiri. Kuyambira pa "matenda a m'mimba" mpaka pano "matenda a matumbo a m'matumbo a metabolites", akufotokozeranso mgwirizano pakati pa matenda ndi zomera zam'mimba. Komabe, pakalipano, kafukufuku wokhudzana ndi kayendetsedwe ka tiyi ndi zigawo zake zogwira ntchito zamaluwa a m'mimba makamaka amayang'ana kwambiri pa kayendetsedwe ka matumbo a m'mimba, kulimbikitsa kukula kwa mabakiteriya opindulitsa komanso kulepheretsa kukula kwa mabakiteriya ovulaza, pamene palibe kafukufuku wokhudzana ndi matenda a m'mimba. ubale weniweni pakati pa tiyi ndi zigawo zake zogwira ntchito zomwe zimayendetsa zomera zam'mimba ndi thanzi la alendo.
Chifukwa chake, potengera chidule cha kafukufuku waposachedwa, pepalali limapanga lingaliro lalikulu la "tiyi ndi zigawo zake zogwira ntchito - m'matumbo am'mimba - metabolites yamatumbo - thanzi la munthu", kuti apereke malingaliro atsopano pakuphunzira ntchito yaumoyo tiyi ndi zigawo zake zinchito.
Chifukwa cha makina osadziwika bwino a "tiyi ndi zigawo zake zogwira ntchito - zomera za m'mimba - matumbo a metabolites - thanzi labwino", chiyembekezo cha chitukuko cha msika wa tiyi ndi zigawo zake zogwira ntchito monga prebiotics ndizochepa. M'zaka zaposachedwa, "kuyankha kwamankhwala payekha" kwapezeka kuti kumagwirizana kwambiri ndi kusiyana kwa zomera za m'mimba. Panthawi imodzimodziyo, ndi malingaliro a malingaliro a "mankhwala olondola", "chakudya cholondola" ndi "chakudya cholondola", zofunikira zapamwamba zimaperekedwa kuti zifotokoze mgwirizano pakati pa "tiyi ndi zigawo zake zogwira ntchito - zomera za m'mimba - matumbo a metabolites - thanzi la alendo”. Pakafukufuku wamtsogolo, ochita kafukufuku akuyenera kufotokozeranso kugwirizana pakati pa tiyi ndi zigawo zake zogwira ntchito ndi zomera za m'mimba mothandizidwa ndi njira zamakono zasayansi, monga kuphatikiza magulu ambiri (monga macrogenome ndi metabolome). Ntchito zaumoyo za tiyi ndi zigawo zake zogwira ntchito zinafufuzidwa pogwiritsa ntchito njira zodzipatula komanso kuyeretsa matumbo a m'mimba ndi mbewa zosabala. Ngakhale makina a tiyi ndi zigawo zake zogwirira ntchito zomwe zimayang'anira zomera za m'mimba zomwe zimakhudza thanzi la alendo sizikudziwika bwino, palibe kukayikira kuti tiyi ndi zigawo zake zimagwira ntchito pa zomera za m'mimba ndizofunikira kwambiri pa thanzi lake.