A odana ndi yotupa komanso yopanda tanthauzo ya tiyi yalembedwa koyambirira kwa synnong herbal. Ndi chitukuko cha sayansi ndi ukadaulo, anthu amalipira zambiri
Ndipo chidwi cha chithandizo cha Thanzi la tiyi. Tiyi ili ndi tiyi polyphenols, tiyi polysaccharides, Theanine, caffeine ndi zina zogwirira ntchito. Ili ndi kuthekera koletsa kunenepa, matenda ashuga, kutupa kwa matenda ndi matenda ena.
Matumbo am'matumbo amadziwika kuti ndi "kagayidwe kagayidwe" ndi "endocrine", womwe umapangidwa ndi micreroorganism ma inroorges. Matumbo a m'matumbo amagwirizana kwambiri ndi kupezeka kwa kunenepa, matenda ashuga, matenda oopsa komanso matenda ena.
M'zaka zaposachedwa, maphunziro ochulukirapo apeza kuti mphamvu yazachipatala ya tiyi imatha kutchulidwa kuti kulumikizana pakati pa tiyi, ntchito zogwirira ntchito ndi matumbo. Chiwerengero chachikulu cha manambala chatsimikizira kuti polyphenols yokhala ndi bioavailability amatha kulowetsedwa ndikugwiritsidwa ntchito ndi tizilombo tating'onoting'ono tomwe timapindula kwambiri. Komabe, kachitidwema kolumikizana pakati pa tiyi ndi matumbo kumakhala kosadziwikiratu. Kaya ndikuwongolera kwa metabolites ya tiyi yogwira ntchito ndi magawo omwe ali ndi tizilombo toyambitsa matenda, kapena mosapita m'mbali tiyi amalimbikitsa kukula kwa tiziromboti topindulitsa m'matumbo opindulitsa.
Chifukwa chake, pepala ili limafotokoza mwachidule kulumikizana pakati pa tiyi ndi zigawo zake ndi matumbo omwe amakhala kunyumba ndi kumatumba a "tiyi ndi zigawo zake zothandizira ntchito ya thanzi la tiyi ndi zigawo zake.

01
Ubale pakati pa utoto wamatumbo komanso homestostasis
Ndi chilengedwe chofunda komanso zosawoneka bwino kwa matumbo a anthu, tizilombo tating'onoting'ono timatha kukula ndikubereka matumbo amunthu, yomwe ndi gawo logwirizana la thupi. Microsbousa yonyamula ndi thupi la munthu imatha kufanana ndi kukula kwa thupi la munthu, ndikukhalabe wokhazikika kwakanthawi komanso kufooka kwaukali mpaka kufa.
Matumbo am'matumbo amatha kukhala ndi chofunikira kwambiri pazachitetezo chamunthu, kagayidwe kagayidwe kazinthu kudzera mu metabolabolites wake wolemera, monga mafuta acita acids (scfas). M'matumbo achikulire athanzi, mabacteridete ndi okhazikika ndiye gulu lalikulu kwambiri, yowerengera maluwa oposa 90% ya maluwa onse, kenako proteobicticrobia.
Microorganism zosiyanasiyana m'matumbo amaphatikizana kwambiri m'matumbo ena, amaletsa ndipo amadalirana wina ndi mnzake, kuti azisunga malire a mathengo a Homestasis. Kupsinjika kwamaganizidwe, zizolowezi zodyedwa, maantibayotiki, mapisi am'matumbo am'matumbo ndi zinthu zina zimawononga matumbo okhazikika, ndipo kusokonezeka kwa matumbo, zomwe zimapangitsa matenda ena ofananira, komanso matenda a ubongo ndi zina zambiri.
Zakudya ndiye chinthu chofunikira kwambiri chomwe chikukhudza maluwa. Zakudya zopatsa thanzi (monga famu ya feber yayitali, prebbo, etc.) imalimbikitsa kuyambika kwa mabakiteriya opindulitsa, kuti apititse patsogolo kusamvana kwa incfas. Zakudya zosayenera (monga shuga wambiri komanso zakudya za calorie) zimasintha kuchuluka kwa mabakiteriya osokoneza boga, pomwe mabakiteriya ambiri osokoneza bongo amalimbikitsa ma lipoplysarnaride (onjezerani kunenepa komanso ngakhale emotoxemia.
Chifukwa chake, zakudya ndizakufunikira kwambiri kuti mukhalebe ndi kuphika homestasis yopanda maluwa, yomwe imagwirizana mwachindunji ndi thanzi la alendowo.

02

Malamulo a tiyi ndi zigawo zake zogwirira ntchito m'matumbo
Pakadali pano, pali zina zodziwika bwino kwambiri mu tiyi, kuphatikiza tiyi polyphenols, tiyi polysaccharides, Theanine, caffeine, khofi ndi zina zotero. Kafukufuku wawonetsa kuti tiyi ndi zinthu zake zogwirizira zimagwira ntchito yofunika kwambiri mumitundu yambiri ya anthu, komanso kulimbikitsa mabakiteriya owopsa monga Elobburiacteryceae ndi Helicobacter.
1. Malamulo a tiyi pamatumbo
Mu mtundu wa colitis wopangidwa ndi dextran sodeum sulfate, nampsone kasanu ndi umodziyo zatsimikiziridwa kuti ndi zotsatirapo zosiyanasiyana zam'matumbo, zomwe zimatha kuwonjezera mitundu yam'matumbo yomwe mwina imakhala ndi mabakiteriya omwe angakhale opindulitsa.

Huang et al. Anapeza kuti kulowererapo kwa tiyi wa pu'er kumatha kusokoneza kwambiri kutupa komwe kumayambitsidwa ndi dextran sodium sulfate; Nthawi yomweyo, mankhwalawa a tiyi wa pu'er amatha kuchepetsa kuchuluka kwa mabakitesite ovulaza, cytobacteteria ndi aftobacteteya, ndikulimbikitsa kuwonjezeka kwa baccernaya, mphamvu ya ruminococcaceae ucg-014. Kuyesa kwa mabakiterite kutsimikizika kutsimikizika kuti tiyi wa pu'er imatha kusintha colitis yoyambitsidwa ndi dextran sodefate sulfate yopanda tanthauzo la maluwa. Kusintha kumeneku kungakhale chifukwa cha kuchuluka kwa scfas ku mbewa ya mbewa ndi kutsegula kwa ma con conic peroxisome γ overtive. Kafukufuku amenewa akuwonetsa kuti tiyi ali ndi zochitika za preziatic, ndipo ntchito yaumoyo imadziwika kuti ndi gawo lake lamatumbo ake.

2. Kuwongolera kwa tiyi polyphenols pamatumbo
Zhu et apeza kuti PEZHhuan Tiyi Polyphenol ingatheke kuchepetsa kuchepa kwa matumbo am'matumbo, kuphatikizapo ankkermansia, mosiyanasiyana Ndipo Faecalis Baculum, ndi mabakiteriya a Fecal amayesanso kuti kunenepa kwa tiyi wa tiyi wa Fuzhuan kumagwirizana mwachindunji ndi matumbo. Wu et al. Kutsimikiziridwa kuti mu mtundu wa colitis yoyambitsidwa ndi dextran sodium sulfate, mphamvu yopumira ya epigalmstanb clulate galuate (mwachitsanzo) ku Colitis imatheka pokonza mitu yamatumbo. Egcg imatha kukonza bwino kuchuluka kwa scfas yopanga tizilombo tating'onoting'ono, monga Ackermann ndi lactobactus. Zotsatira za tiyi polyphenols zimatha kuchepetsa kuchepa kwa matumbo. Ngakhale bakisi ya taxi yomwe imayendetsedwa ndi magwero osiyanasiyana a tiyi ma polyphenols atha kukhala osiyana, palibe kukayika kuti thanzi la tiyi ma polyphenols amagwirizana kwambiri ndi matumbo.
3. Malamulo a tiyi polysaccharide pamatumbo
Ma polysaczaccharades amatha kuwonjezera mitundu yam'matumbo yamatumbo. Inapezeka m'matumbo a plubetion plube dots kuti ma polyschackudes amatha kuwonjezera kuchuluka kwa tizilombo tating'onoting'ono tomwe timapanga, ndikusintha kagayidwe ka shuga. Nthawi yomweyo, mtundu wa colitis wopangidwa ndi dextran sodeum sulfate, zomwe zimapangitsa kuti ziphuphuzi zikhale zotchinga komanso zotchinga matumbo ndi kutupa. Chifukwa chake, tiyi polysar, zimatha kulimbikitsa kukula kwa tizilombo topindulitsa monga scfas komanso kulepheretsa kukula kwa ma microorganiss, kuti azikhala ndi matope am'matumbo am'matumbo.
4. Kuwongolera kwa zinthu zina zogwirira ntchito mu tiyi m'matumbo
Tiyi sapomin, omwe amatchedwanso ti timphan, ndi mtundu wa mankhwala a glycoside omwe ali ndi mapangidwe ovuta kuchokera ku nthangala za tiyi. Imakhala ndi kulemera kwakukulu kwa maselo, polarity wamphamvu ndipo ndikosavuta kusungunuka m'madzi. Li yu ndi ena omwe adadyetsa ana a Nawalewa ndi tiyi pensonin. Zotsatira zakuwunika kwamatumbo kuwunika kunawonetsa kuti mabakiteriya ambiri opindulitsa okhudzana ndi kukweza kwa chitetezo cha thupi ndi mabakiteriya oopsa kwambiri okhudzana ndi matenda a thupi omwe amawonongedwa kwambiri. Chifukwa chake, sapomin a tiyi ali ndi zotsatira zabwino pamphato wa ana a nkhosa. Kulowererapo kwa saponin ya tiyi kumatha kuwonjezera mitundu yosiyanasiyana yamitu yosiyanasiyana ya homestis, ndikuwonjezera chitetezo chitetezo cha thupi.
Kuphatikiza apo, zigawo zazikuluzikulu zopangira tiyi zimaphatikizaponso Aanine ndi caffeine. Komabe, chifukwa cha bioavailability wa Thenine, caffeine ndi zina zogwirira ntchito, mayamwidwe atsirizidwa asanafike m'matumbo akuluakulu, pomwe matumbo amagawidwa makamaka m'matumbo akuluakulu. Chifukwa chake, kuyanjana pakati pawo ndi matumbo sikudziwika.

03
Tiyi ndi zigawo zake zogwirira ntchito zimayendetsa matumbo
Njira zomwe zingatheke
Lipinski ndi ena amakhulupirira kuti mankhwala otsika a bioavailabichi amakhala ndi mawonekedwe otsatirawa: (1) Kulemera kwa matope> 500, Logp> 5; (2) Kuchuluka kwa - o kapena - NH mu gawo ndi ≥ 5; .
Komabe, kafukufuku wasonyeza kuti mafuta awa amatha kukhala michere ya m'matumbo. Mbali inayi, zinthu zosasunthika izi zimatha kunyozedwa mu zinthu zazing'ono zogwira ntchito monga mayamwidwe amtunduwu komanso kugwiritsidwa ntchito potenga nawo matumbo. Kumbali ina, zinthu izi zimathanso kuyendetsa bwino matumbo, kulimbikitsa kukula kwa ma scroorganisganis opindulitsa monga scfas ndipo imalepheretsa kukula kwa microorganism yopanga monga LPS.
Koropatkin Et AL apeza kuti matumbo athamitsere a Polysaccharides mu tiyi mu metabolites oyambitsidwa ndi scfas kudutsa kuwonongeka koyambirira komanso kuwonongeka kwachiwiri. Kuphatikiza apo, ma polyphenols m'matumbo omwe samayankhidwa mwachindunji komanso kugwiritsidwa ntchito ndi thupi la munthu nthawi zambiri amasinthidwa kukhala mankhwala ochulukirapo, ma acids phenolic acid ndi zinthu zomwe zimachitika chifukwa chazomwe zimayamwa komanso kugwiritsa ntchito.
Maphunziro ambiri atsimikizira kuti tiyi ndi zigawo zake zogwirizira zimakonda kusintha matope osiyanasiyana, kulimbikitsa kukula kwa mabakiteriya othandiza komanso kugwiritsira ntchito ma metmisiliation. Kuphatikizidwa ndi kusanthula mabuku, makina a tiyi, zigawo zake ndi matumbo ake matumbo okhudzidwa atha kuonedwa mu magawo atatu otsatirawa.
1. Tiyi ndi zigawo zake zogwirizira - matumbo a maluwa - scfas - makina a Healtury of Health
Mitundu ya matumbo ya m'matumbo ndi nthawi 150 kuposa majini a anthu. Kusiyanasiyana kwa ma microorganisms kumapangitsa kuti kukhala ndi ma enzymes a mezabolizi omwe omwe ali nawo alibe, ndipo amatha kusuntha michere yambiri yomwe thupi laumunthu limasowa ku Morsaccharides ndi Scfas.
Scfas imapangidwa ndi nayonso mphamvu ndi kusinthika kwa chakudya chosasinthika m'matumbo. Ndiye metiabolite ya tizilombo tating'onoting'ono kumapeto kwa matumbo, makamaka kuphatikiza acetic acid, pro prictic acid ndi ntyyric acid. Scfas imawerengedwa kuti ndi yogwirizana kwambiri ndi shuga ndi kagayidwe, zotupa m'matumbo, zotchinga zamatumbo, matumbo kuyenda ndi chitetezo. Mu mtundu wa colitis wopangidwa ndi dextran sodium sulfate, tiyi amatha kuwonjezera kuchuluka kwa scfas mu mbewa mu mbewa ndikuwonjezera zomwe zili ndi ma ndowa, kuti muchepetse kutupa. Pu'er tiyi polysaride imatha kuwongolera kwambiri matoma, kulimbikitsa kukula kwa scfis kupanga tizilombo tating'onoting'ono ndikuwonjezera ndowe pazinthu za mbewa. Zofanana ndi polysaccharides, kudya tiyi ma polyphenols amathanso kuwonjezera kuchuluka kwa scfas ndikulimbikitsa kukula kwa scfis kupanga tizilombo tating'onoting'ono. Nthawi yomweyo, Wang et al adawona kuti kudya kwa Aarubinin angakulitse kuchuluka kwa maluwa ochulukitsa, makamaka mapangidwe a acid, makamaka mapangidwe a mikangano yopangidwa ndi zakudya zonenepa kwambiri.
Chifukwa chake, tiyi ndi zinthu zake zogwirizira zimatha kulimbikitsa kukula ndi kubereka kwa ScFAS kupanga microorganisganis pokonza matumbo am'matumbo, kuti azigwira ntchito yofananira ndi thanzi.

2. Tiyi ndi zigawo zake zogwira ntchito - matumbo a maluwa - bad - njira yaumoyo wa Health
Bile Acid (Bas) ndi mtundu wina wa mankhwala omwe ali ndi zotsatira zabwino zaumoyo, zomwe zimapangidwa ndi hepatocytes. The Bile acids acids Oftrasizeted mu chiwindi kuphatikiza ndi a Glycine ndipo amalowetsedwa m'matumbo. Ndiye zochita zingapo monga dehydroxtylation, njira zosiyanirana ndi makutidwe ndi oxidation zimachitika pansi pamatumbo am'matumbo, ndipo pamapeto pake bile bile zimapangidwa. Chifukwa chake, maluwa matumbo amachita mbali yofunika kwambiri pa kagayidwe kake.
Kuphatikiza apo, zosintha za basi zimagwirizana kwambiri ndi shuga ndi mafuta kagayidwe, zotchinga matumbo ndi kutupa. Kafukufuku wawonetsa tiyi wa pu'er ndi Theabratonin imatha kuchepetsa cholesterol ndi lipid poletsa ma bile mchere hydrolase acids. Kudzera munthawi yophatikizira ya egcg ndi caffeine, zhu et al. Anapeza kuti gawo la tiyi pochepetsa kuchepa mafuta komanso kunenepa ndi caffeine cace tourth acids, kusintha bile acid acid.
Chifukwa chake, tiyi ndi zomwe zimagwira ntchito zimayendetsa kukula ndi kubereka kwa ma microorganisganisms okhudzana ndi kagayidwe kake kake, kenako ndikusintha mabii acidid mthupi, kuti azichepetsa kuchepa kwa lipid.
3. Tiyi ndi zigawo zake - matumbo amatabwa - matumbo ena a metabolites - njira yoyendetsera thanzi la Health
LPS, yomwe imadziwikanso kuti Petulo, ndiye gawo lakunja la mabakiteriya a Gram-siment. Kafukufuku wasonyeza kuti kusokonezeka kwa matumbo kwamphamvu kudzapangitsa kuwonongeka kwa zotchinga matumbo, mafayilo amalowa mu kufalitsidwa, kenako kumabweretsa zotupa zingapo. Zuo Gaolong et al. Anapeza kuti tiyi wa Fuzhuan unachepetsa kwambiri kuchuluka kwa ma roramu makoswe okhala ndi matenda osaneneka a chiwindi, ndipo kuchuluka kwa mabakiteriya olakwika m'matumbo omwe mainpirini amatsika kwambiri. Zinanenedwanso kuti tiyi wa Fuzhuan amatha kuletsa kukula kwa mabakiteriya opanga mabulosi omwe amatulutsa matope.
Kuphatikiza apo, tiyi ndi magawo ake ogwirira ntchito amathanso kuyendetsanso ma metabolites osiyanasiyana matumbo kudzera m'matumbo, monga mafuta acids antin, mavitamini K2 ndi zinthu zamilomo ndikuteteza mafupa.

04
Mapeto
Monga m'mphepete mwa zakumwa zodziwika kwambiri padziko lapansi, ntchito ya thanzi la thanzi laphunzitsidwa kwambiri m'maselo, nyama ngakhale thupi la munthu. M'mbuyomu, nthawi zambiri zimaganiziridwa kuti thanzi la tiyi limakhala lopanda tanthauzo makamaka, otsutsa-kutupa, anti-oxidation ndi zina zambiri.
M'zaka zaposachedwa, kuphunzira kwamatumbo pang'onopang'ono kwapang'onopang'ono. Kuyambira koyamba "matenda am'matumbo a m'matumbo" mpaka pano "agogomezera maluwa am'mimba m'matumbo", zimathandizanso ubale pakati pa matenda ndi mitu yamatumbo. Komabe, pakalipano, kafukufuku pa malamulo a tiyi ndi zigawo zake zogwirira ntchito m'matumbo makamaka zimayang'ana kwambiri mabakiteriya owopsa, pomwe pali kusowa kwa kafukufuku wa Tiyi ndi zigawo zake zomwe zimayendetsedwa m'matumbo komanso thanzi lake.
Chifukwa chake, kutengera mwatsatanetsatane mwatsatanetsatane maphunziro ofunikira aposachedwa, pepala ili limapanga lingaliro lalikulu la "tiyi ndi zigawo zake zamatumbo - matumbo a Heastol", kuti apereke malingaliro atsopano pophunzira ntchito ya thanzi la tiyi ndi zigawo zake.
Chifukwa cha zojambulajambula za "Tiyi ndi zigawo zake - matumbo amatamba - chizolowezi cha chizolowezi", chiyembekezo cha msika " M'zaka zaposachedwa, "yankho la mankhwala" lapezeka kuti likugwirizana kwambiri ndi kusiyana kwa matumba. Nthawi yomweyo, ndi lingaliro la malingaliro a "mankhwala olondola", "chakudya chofatsa" komanso "zofunika kwambiri ndikuyika patsogolo pomveketsa ubale pakati pa" tiyi ndi ma metabolites ". M'tsogolo kafukufuku, ofufuza ayenera kufotokozeranso kulumikizana pakati pa tiyi ndi zigawo zake ndi matumbo ake mothandizidwa ndi njira zambiri zapamwamba, monga macrogenome ndi metabolome komanso metabolome). Ntchito zaumoyo wa tiyi ndi zigawo zake zogwirira ntchito zidayendetsedwa pogwiritsa ntchito maluso a kudzipatula komanso kuyeretsa matumbo ndi mbewa zosabala. Ngakhale zimapangitsa tiyi ndi zigawo zake zomwe zimayendetsedwa m'matumbo zomwe zikukhudza thanzi lambiri sizikumveka, palibe chikaiko kuti chitsimikiziro cha tiyi ndi zogwirizira zake zamatumbo ndi chonyamulira chofunikira kwambiri.