Tiyi wakuda, yemwe wafufuma, ndiye tiyi wodyedwa kwambiri padziko lapansi. Ikakonzedwa, imayenera kufota, kugudubuza ndi kuwira, zomwe zimapangitsa kuti zinthu zomwe zili m'masamba a tiyi zikhale zovuta kwambiri ndipo pamapeto pake zimabala kukoma kwake komanso thanzi. Posachedwapa, gulu lofufuza lotsogozedwa ndi Prof. WANG Yuefei wochokera ku College of Agriculture ndi Biotechnology, Zhejiang University, lapita patsogolo kwambiri pokhudzana ndi mapangidwe abwino ndi ntchito ya thanzi la tiyi wakuda.

Pogwiritsa ntchito kuwunika kwamalingaliro ndi metabolomics kusanthula zotsatira za magawo osiyanasiyana opangira zinthu pamitundu yosasinthika komanso yosasinthika ya tiyi wakuda wa Zijuan, gululo lidapeza kuti phenylacetic acid ndi glutamine zinali zogwirizana kwambiri ndi fungo ndi kukoma kwa tiyi wakuda wa Zijuan, motsatana, potero kupereka chiwongolero cha kukhathamiritsa kwa njira yopangira tiyi yakuda ya Zijuan (Zhao et al., LWT -Sayansi Yazakudya ndi Zamakono, 2020). M'maphunziro otsatirawa, adapeza kuti kuchuluka kwa okosijeni kumatha kulimbikitsa makatekini, flavonoid glycosides ndi phenolic acid, komanso ma catechins oxidation amatha kufulumizitsa kuwonongeka kwa ma amino acid kuti apange aldehydes osakhazikika komanso kulimbikitsa makutidwe ndi okosijeni a phenolic acid, potero amachepetsa astringency ndi kuwawa komanso kukulitsa umamidi. , zomwe zimapereka chidziwitso chatsopano cha oyenerera mapangidwe a tiyi wakuda. Zotsatira zafukufukuzi zidasindikizidwa m'nkhani yamutu wakuti "Kutentha kwa oxygen kumawonjezera kukoma kwa tiyi wakuda pochepetsa ma metabolites owawa ndi astringent" m'magazini.Food Research Internationalmu Julayi, 2021.

Kusintha kwa ma metabolites osasinthika panthawi yakukonzedwa kumakhudzanso momwe tiyi wakuda amagwirira ntchito komanso thanzi. Mu Novembala 2021, gululo lidasindikiza nkhani yotseguka yamutu wakuti "Kusintha kwa metabolite kosasunthika panthawi yopanga tiyi wakuda wa Zijuan kumakhudza chitetezo cha ma HOEC omwe ali ndi chikonga" m'magazini.Chakudya & Ntchito. Kafukufukuyu adawonetsa kuti leucine, isoleucine, ndi tyrosine ndizo zida zazikulu za hydrolysis panthawi yofota, ndi theaflavin-3-gallate (TF-3-G), theaflavin-3'-gallate (TF-3'-G) ndi theaflavin-3 , 3'-gallate (TFDG) idapangidwa makamaka pakugubuduza. Kuphatikiza apo, makutidwe ndi okosijeni a flavonoid glycosides, makatechini ndi makatechini a dimeric anachitika panthawi yowitsa. Pa kuyanika, kutembenuka kwa amino acid kunakhala kwakukulu. Kusintha kwa ma theaflavins, ma amino acid ena ndi flavonoid glycosides kudakhudza kwambiri kukana kwa tiyi wakuda wa Zijuan kuvulala kwapakamwa kwa epithelial cell, zomwe zikuwonetsa kuti kukhathamiritsa kwa zosakaniza zinazake komanso kupititsa patsogolo ntchito zapadera za tiyi wakuda pakuwongolera. kupanga tiyi wakuda kungakhale lingaliro lanzeru pakukonza tiyi.

Mu Disembala 2021, gululo lidasindikizanso nkhani ina yamutu wakuti "Tiyi Yakuda Imachepetsa Kuvulala Kwapamapapo Kwapapapo kudzera pa Gut-Lung Axis in Mice"Journal yaChemistry yaulimi ndi Chakudya. Kafukufukuyu adawonetsa kuti mbewa za PM (zinthu zazing'ono) - zowonekera zimawonetsa kupsinjika kwa okosijeni ndi kutupa m'mapapo, komwe kumatha kuchepetsedwa kwambiri ndikumwa tsiku lililonse kulowetsedwa kwa tiyi wakuda wa Zijuan modalira kwambiri. Chochititsa chidwi n'chakuti, kagawo kakang'ono ka ethanol-soluble (ES) ndi kagawo kakang'ono ka ethanol precipitate (EP) adawonetsa zotsatira zabwino kuposa za TI. Kuphatikiza apo, fecal microbiota transplantation (FMT) idawulula kuti matumbo a microbiota adasinthidwa mosiyanasiyana ndi TI ndipo tizigawo tating'ono tating'ono titha kuthetseratu kuvulala komwe kunayambitsidwa ndi PMs. Komanso, aLachnospiraceae_NK4A136_guluikhoza kukhala kachilombo koyambitsa matenda komwe kamathandizira kuteteza EP. "Zotsatirazi zikuwonetsa kuti kudya tsiku ndi tsiku kwa tiyi wakuda ndi tizigawo ting'onoting'ono, makamaka EP, kungathandize kuchepetsa kuvulala kwa mapapo chifukwa cha PM kudzera m'matumbo a m'mapapo mu mbewa, motero kupereka maumboni okhudzana ndi thanzi la tiyi wakuda," adatero Wang.