Tea yana daya daga cikin manyan abubuwan sha guda uku na duniya, masu arziki a cikin polyphentols, tare da antioxidant, hypolipipidemic, hypollipipipipipipicmic, hypololipipipipipipipich, hypololipipipipipipipich, hypololipipipipiphicm da sauran ayyukan kiwon lafiya da ayyukan kiwon lafiya. Shayi za a iya raba shayi mara fermarin da ba fermented ba, shayi mai da shayi mai bayan-fure gwargwadon fasahar sarrafawa da kuma fermentation. Shafaffen post-fermed yana nufin shayi tare da shiga cikin fermentation, kamar PU 'er' er ya samar da shayi, da Kippukuo, shayi na kasar Sin, da sarriijin da Kuroyamacha samar a Japan. Wadannan microbial sun ƙaunace su da mutane masu tasirin kiwon lafiya kamar su rage mai kitsen jini, sukari na jini da cholesterol.

Bayan an canza shi na ƙwayoyin cuta, polyphena na shayi a cikin shayi yana canzawa ta Enzymes da kuma polyphenols da yawa tare da sabbin tsare-tsaren an kafa. TeAfienol a da Teadenol B sune kayan kwalliyar polyphenol na ware daga shayi mai cike da shayi mai kyau tare da aspergillus sp (Pk-1, Farm AP-21280). A cikin wani bincike mai zuwa, an gano shi cikin yawan shayi mai fermed. Teadenols suna da Stereoisomers biyu, Cis-Teadeenol A da Trans-Tereenol B. Tsarin Tsarin Cycania mai kama da Farin Cypane 3-Perbuls da kuma hotunan zobe abubuwan zama. TeAfienol a da Teadeenol B ana iya zama biosynhecized daga EGCG da GCG bi da bi.

A cikin bincike mai zuwa, an gano cewa Teadenols yana da ayyukan nazarin halittu kamar inganta Asiboneectin m, wanda ke jawo hankalin masu binciken da yawa. Adiponeectin shine takamaiman takamaiman polypeptide zuwa adipose nama, wanda zai iya rage abin da ya faru game da rikice-rikice na rayuwa a cikin nau'in ciwon sukari na II. PTP1B a halin yanzu ana gane shi a matsayin manufa mai cuta ga masu ciwon sukari da kiba, suna nuna cewa Teadenols yana da tasirin hypoglycemic da kuma tasirin asarar nauyi.

A cikin wannan takarda, gano abubuwan, biosynthesis, duka adadi da kuma rashin daidaituwa na TeAfiails an sake nazarin shayi na kimiyya da amfani da Teadenols.

▲ ta zahiri hoto hoto

01

Gano Teadenols a cikin shayi mai cinyewa

Bayan an samo tepergills daga aspergillus sp (Pk-1280) ferment) Ferment) Ferment) Fermates na farko, MS-MS / MS an yi amfani da Teadenols a cikin nau'ikan shayi daban-daban. Nazarin ya nuna cewa Teadenols suna wanzu a cikin shayi mai ferrobal.

▲ ta, tb ruwa chromatogram chromatogram

Er taro m taro na shayi mai fermobial da Ta da TB

Aspergillus Oryzae SP.PK-1, Farm AP-21280, Aspergillus Awamori Spr.Ao-1, NBRS 4214, Aspergillus Oryzae Sporzae Sporzae Sporzae KA-1, Farmp AP-21291, an gano juna daban-daban na TeAficha, Surokiiso, Yamabuyarish, da kuma a cikin shayi na PU Erh, shayi na kasar Pu Erh, shayi na kasar Sin da Fu Brick na kasar Sin.

Abubuwan da ke cikin TeAfiSols a cikin teas daban-daban sun bambanta, wanda aka tsinke don lalacewa ta hanyar sarrafawa daban-daban da yanayin fermentation.

Commarin karatu ya nuna cewa abubuwan da ke cikin Teadenols a cikin shayi na shayi, kamar su kore shayi da farin shayi, yana da rauni a kasa. Ana nuna abun ciki na Teadenol a cikin ganyen tumatir da yawa a cikin Table 1.

02

AACOCALICTICKY NA TALALENOLS

Karatun ya nuna cewa Teadenols na iya inganta asarar nauyi, yaki da ciwon sukari, hana yaduwar sel da sokin cutar kansa da fari.

TeAfienol a Iya Inganta ADIPONECIN ABINGENT. Adiponeactin shine mai ƙwarewa mai kyau wanda Adipocytes da kuma takamaiman takamaiman zuwa nama mai kyau. Yana da mummunar magana tare da visarfin adipose nama kuma yana da anti-mai kumburi da kayan anti-Atherclerotics. Don haka Teeadenol yana da damar rasa nauyi.

Teadenol wani kuma yana hana bayyana furucin Tyrosiry 1B (PTP1b), wani mummunan rawar gani a cikin insulin na insulin kuma a halin yanzu ana gane shi a matsayin manufa mai ciwon hakori ga ciwon sukari. TeAfienol a iya daidaita insulin ta hanyar inbhibited PTP1B magana. A halin yanzu, Tomotaka et al. Ya nuna cewa Teadenol a ligand ne na dogon-sarkar kitse gpr120, wanda zai iya yin laushi da kuma kunna GPRACON HORMT1 1 a cikin sel na Insulin Stc-1. GLP-1 yana hana ci abinci da kuma ƙara insulin asarar, yana nuna tasirin ciwon sukari. Saboda haka, Teeadenol a yana da tasirin antitiabetic sakamako.

Ka'idojin IC50 na ayyukan DPPH SCVAVE na DPPH SCVEGEGET na tsattsarkan ayyukan Supereroxide na Teadenol a cikin 64.8 μG / ml, bi da bi. Ka'idojin IC50 na jimlar antioxidant mai iya aiki da ƙarfin hydrogen sun kasance 17.6 u / ml da 12 u / ml, bi da bi. Hakanan an nuna cewa cire shayi dauke da Teadeol B yana da sel mai tasowa da sel na HT-29, Caspase-9, Mutuwa Catpasond da Mitochasondrial apoptosis.

Bugu da kari, Teadenols aji ne na polyphenols wanda zai iya whiten fata ta hanyar inbhibed aiki da aiki da melanin kira.

03

Da synthesis na Teadenols

Kamar yadda za a iya gani daga bayanan bincike a cikin Table 1, teadenols a cikin shayi mai amfani da shayi mai lalacewa da tsarkakewa, wanda ke da wuya a cika bukatun bincike da ci gaban aikace-aikace. Sabili da haka, malamai sun gudanar da karatu a kan hanyar irin waɗannan abubuwa daga hanyoyin biyu na BioTransptionsu da kayan kwalliya.

Wulandari et al. Inoculated Aspergillus sp (Pk-1, Farm AP-21280) A cikin hadeci gauraye na haifuwa Egcg da GCG. Bayan makonni 2 na al'ada a 25 ℃, an yi amfani da HPLC don bincika tsarin matsakaici na matsakaici. Teadenol a da Teadeol B an gano su. Daga baya, Aspergillus Oryzae A. Awamori (NurperGillus Oryzae A. Kawachii (Ifloii TeAfienol a da Teadenol B an gano su a duka matsakaici. Wadannan karatun ya nuna cewa canjin microbial da GCG na iya samar da Teadeenol a da Teadenol B. Wajan et al. Amfani da EGCG a matsayin albarkatun kasa da kuma inoculated aspergillus sp don yin nazarin yanayin samar da Teadeenol a da na ruwa da kuma m al'ada. Sakamakon da aka nuna cewa daidaitaccen Czeek-dox matsakaici wanda ke ɗauke da 5% egcg da 1% kore shayi foda yana da mafi yawan amfanin ƙasa. An gano cewa Bugu da ƙari na kore shayi na foda bai shafi samar da Teadenol a da Teadenol b, amma galibi ya haifar da karuwa a cikin adadin Biosynthase da hannu. Bugu da kari, Yoshida et al. Haɗin kai Teadenol a da Teadenol B daga phleloglucinol. Mabuɗin matakan kira sun kasance masu ɗaukar hoto α -abinoxy Catalytic dauki na kwayoyin halitta na kwayoyin cuta na palladium-catalzed phenol.

▲ Ule Ule Ulelways na shayi fermentation

04

Nazarin aikace-aikacen Teadenols

Sakamakon aikinsa mai mahimmanci, an yi amfani da Teadenols mai mahimmanci a cikin magunguna, abinci da abinci, kayan kwalliya, gano masu haɓakawa da sauran filayen.

Akwai samfuran da suka danganci samfuran da ke ɗauke da Teadenols a cikin filin abinci, kamar su shayi na Jafananci slimming da fermeded shayi polyphentols. Bugu da kari, 'yanagida et al. Tabbatar da cewa kwayar shayi dauke da Teadeyol a da Teadenol B ana iya amfani da shi zuwa aikin abinci, kayan abinci, abincin dabbobi da kayan kwalliya. ITO AL. Shirya wakilin talabijin na fata wanda ke dauke da Teadenols tare da sakamako mai ƙarfi wanda ke da tasiri mai ƙarfi, sadad da tsayayyar tasirin da kuma tasirin anti-ussion. Hakanan yana da tasirin kula da kuraje, yana da danshi, infictarged kamuwa da Uv-da aka samo shi da kumburin kumburi da kuma matsa lamba.

A China, ana kiran fu shayi. Masu bincike sun gudanar da bincike da yawa akan kwantar da shayi ko dabarun fili da ke da shayi mai shayi, asarar nauyi, hauhawar jini, hauhawar jini da taushi. Babban mai shayi mai shayi mai tsarkakewa da kuma shirya ta Zhao Ming et al. Za a iya amfani da shi don shirye-shiryen magunguna na Antiplip. Yana Zhihong et al. Da sanya shayi capsules, Allunan ko granulas da granular da ke cikin duhu shayi na Fu A da fu B, ragewar 'yan ta'adda da sauran sakamako masu lalacewa a kan asarar nauyi. Tan Xiao 'Ao ya shirya wannan shayi na Fuzhuan tare da Fuzhuan B, jikin mutum yana da sauki a rage hyperlipia, hyperglycemia, hauhawar jini da taushi jini.

05

"Yare

TeAfidols sune B-ring Lichin na abubuwan data kasance a cikin naman alade mai fermerial, wanda za'a iya samu daga yanayin canjin ƙwayar cuta na Epigallatechin Galle ko daga daidaitaccen tsarin phleloglullinol. Karatun ya nuna cewa Teadenols suna ƙunshe a cikin teas daban-daban cermemed. Abubuwan sun hada da shayi na Nigergillus shayi fermed, Aspergillas oryzae fermedered shayi, Kippbukucha (Japan), Yagoyamacha (Japan), yana da Gentok U-Cha (Japan), Sa'ad da Bancha (Japan), Goshi-Cha (Japan), PU 'Tea, amma abin da ke cikin Teadenols a cikin teas fruasumantacce ne. Abubuwan da ke cikin Teadenol A da B sun shiga daga 0.01% zuwa 6.98% da 0,01% zuwa 0.54%, bi da bi. A lokaci guda, Oolong, Farar fata, Green da Black teas basu ƙunshi waɗannan mahadi.

Har zuwa yanzu bincike na yanzu yana da damuwa, karatu a kan teadenols har yanzu yana da iyaka, wanda ya shafi kawai tushen, da sauran hanyoyin aiki da aikace-aikace da aikace-aikace suna buƙatar bincike da yawa. Tare da ƙarin bincike, mahaɗan Teeadenols za su sami ƙimar ci gaba da manyan abubuwan aikace-aikace.